6-溴-5-氟吡啶-2-羧酸
6-Bromo-5-fluoropyridine-2-carboxylic acid
CAS: 1052714-46-1
Molecular Formula: C6H3BrFNO2
6-溴-5-氟吡啶-2-羧酸 - Names and Identifiers
| Name | 6-Bromo-5-fluoropyridine-2-carboxylic acid |
| Synonyms | 6-BroMo-5-fluoropicolinic acid 6-Bromo-5-fluoro-2-pyridinecarboxylic acid 6-Bromo-5-fluoropyridine-2-carboxylic acid 2-Pyridinecarboxylic acid, 6-broMo-5-fluoro- |
| CAS | 1052714-46-1 |
| InChI | InChI=1S/C6H3BrFNO2/c7-5-3(8)1-2-4(9-5)6(10)11/h1-2H,(H,10,11) |
6-溴-5-氟吡啶-2-羧酸 - Physico-chemical Properties
| Molecular Formula | C6H3BrFNO2 |
| Molar Mass | 220 |
| Density | 1.903 |
| Boling Point | 331.3±42.0 °C(Predicted) |
| pKa | 3.19±0.10(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
6-溴-5-氟吡啶-2-羧酸 - Risk and Safety
| UN IDs | UN2811 |
6-溴-5-氟吡啶-2-羧酸 - Introduction
6-bromo-5-fluoro-2-picolinic acid, also known as 5-fluoro-2-bromopicolinic acid, chemical formula C6H3BrFNOC, is an organic compound. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: colorless crystal
-melting point: 155-157 ℃
-Boiling point: 355 ℃
-Solubility: Slightly soluble in water, soluble in organic solvents such as ether, chloroform and methanol
Use:
6-Bromo-5-fluoro-2-picolinic acid is mainly used as a catalyst or ligand in organic synthesis. It can be used for the synthesis of compounds containing 5-fluoro-2-bromopyridine structure, such as heterocyclic compounds in organic synthesis, drugs, pesticides and other organic chemistry research.
Preparation Method:
There are many ways to prepare 6-bromo-5-fluoro-2-picolinic acid. The following is one of the commonly used methods:
In a reactor, 5-fluoro-2-pyridinecarboxylic acid is reacted with concentrated bromine solution, and the product of 6-bromo-5-fluoro-2-pyridinecarboxylic acid is obtained through the steps of reaction, separation and crystallization.
Safety Information:
1. 6-Bromo-5-fluoro-2-picolinic acid Avoid contact with skin and eyes during handling and storage to prevent inhalation or swallowing.
2. Wear appropriate protective equipment such as lab gloves, goggles and protective clothing when handling this compound.
3. Make sure to operate in a well-ventilated area and keep away from fire and heat sources.
4. In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical help if necessary.
5. When storing, it should be stored in a sealed container and placed in a dry and cool place, away from combustibles and oxidants.
Be sure to read and follow the relevant safety instructions and precautions before using 6-bromo-5-fluoro-2-picolinic acid.
Nature:
-Appearance: colorless crystal
-melting point: 155-157 ℃
-Boiling point: 355 ℃
-Solubility: Slightly soluble in water, soluble in organic solvents such as ether, chloroform and methanol
Use:
6-Bromo-5-fluoro-2-picolinic acid is mainly used as a catalyst or ligand in organic synthesis. It can be used for the synthesis of compounds containing 5-fluoro-2-bromopyridine structure, such as heterocyclic compounds in organic synthesis, drugs, pesticides and other organic chemistry research.
Preparation Method:
There are many ways to prepare 6-bromo-5-fluoro-2-picolinic acid. The following is one of the commonly used methods:
In a reactor, 5-fluoro-2-pyridinecarboxylic acid is reacted with concentrated bromine solution, and the product of 6-bromo-5-fluoro-2-pyridinecarboxylic acid is obtained through the steps of reaction, separation and crystallization.
Safety Information:
1. 6-Bromo-5-fluoro-2-picolinic acid Avoid contact with skin and eyes during handling and storage to prevent inhalation or swallowing.
2. Wear appropriate protective equipment such as lab gloves, goggles and protective clothing when handling this compound.
3. Make sure to operate in a well-ventilated area and keep away from fire and heat sources.
4. In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical help if necessary.
5. When storing, it should be stored in a sealed container and placed in a dry and cool place, away from combustibles and oxidants.
Be sure to read and follow the relevant safety instructions and precautions before using 6-bromo-5-fluoro-2-picolinic acid.
Last Update：2024-04-09 15:17:50
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View History
6-溴-5-氟吡啶-2-羧酸
3-[3-(DIETHYLAMINO)PROPYL]-2-MERCAPTOQUINAZOLIN-4(3H)-ONE
6-(BOC-氨基)螺[3.3]庚烷-2-羧酸甲酯
1H-Imidazole-1-propanol, 2-nitro-β-[(tetrahydro-2H-pyran-2-yl)oxy]-, 1-(4-methylbenzenesulfonate)
2-(6-(三氟甲基)咪唑并[1,5-a]吡啶-3-基)乙酸
M-IODOBENZOIC ACID METHYL ESTER
2-氯-6-氟喹啉-3-羧酸
2-[8-(1,4-dioxa-8-azaspiro[4.5]decyl)methyl]-2'-thiomethyl benzophenone
GLYCERYL TRIHEPTANOATE
3-[3-(DIETHYLAMINO)PROPYL]-2-MERCAPTOQUINAZOLIN-4(3H)-ONE
6-(BOC-氨基)螺[3.3]庚烷-2-羧酸甲酯
1H-Imidazole-1-propanol, 2-nitro-β-[(tetrahydro-2H-pyran-2-yl)oxy]-, 1-(4-methylbenzenesulfonate)
2-(6-(三氟甲基)咪唑并[1,5-a]吡啶-3-基)乙酸
M-IODOBENZOIC ACID METHYL ESTER
2-氯-6-氟喹啉-3-羧酸
2-[8-(1,4-dioxa-8-azaspiro[4.5]decyl)methyl]-2'-thiomethyl benzophenone
GLYCERYL TRIHEPTANOATE