6-METHYLNICOTINONITRILE
5-Cyano-2-methylpyridine
CAS: 3222-48-8
Molecular Formula: C7H6N2
6-METHYLNICOTINONITRILE - Names and Identifiers
| Name | 5-Cyano-2-methylpyridine |
| Synonyms | 5-Cyano-2-picoline 5-CYANO-2-PICOLINE 6-Methylnicotinonitrile 6-METHYLNICOTINONITRILE 5-CYANO-2-METHYLPYRIDINE 3-CYANO-6-METHYLPYRIDINE 5-Cyano-2-methylpyridine 6-methylpyridine-3-carbonitrile 6-Methylpyridine-3-carbonitrile 5-Cyano-2-picoline~6-Methylnicotinonitrile 5-Cyano-2-picoline~6-Methylnicotinonitrile~6-Methylpyridine-3-carbonitrile |
| CAS | 3222-48-8 |
| EINECS | 677-851-5 |
| InChI | InChI=1/C7H6N2/c1-6-2-3-7(4-8)5-9-6/h2-3,5H,1H3 |
| InChIKey | PBLOYQAQGYUPCM-UHFFFAOYSA-N |
6-METHYLNICOTINONITRILE - Physico-chemical Properties
| Molecular Formula | C7H6N2 |
| Molar Mass | 118.14 |
| Density | 1.08±0.1 g/cm3(Predicted) |
| Melting Point | 83-85°C |
| Boling Point | 216-217°C |
| Flash Point | 216-217°C |
| Vapor Presure | 0.096mmHg at 25°C |
| Appearance | powder to crystal |
| Color | White to Light yellow |
| BRN | 111235 |
| pKa | 2.51±0.10(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.531 |
| MDL | MFCD00038042 |
6-METHYLNICOTINONITRILE - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R41 - Risk of serious damage to eyes R25 - Toxic if swallowed |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S39 - Wear eye / face protection. |
| UN IDs | 3439 |
| WGK Germany | 1 |
| Hazard Note | Harmful |
| Hazard Class | 6.1 |
| Packing Group | III |
6-METHYLNICOTINONITRILE - Introduction
5-cyano-2-methylpyriridine is an organic compound with the chemical formula C7H6N2. The following is a description of its nature, use, preparation and safety information:
Nature:
5-cyano-2-methylpyrridine is an organic compound with pyridine structure, which is colorless to light yellow liquid in appearance. It has a melting point of -29°C and a boiling point of 184-185°C. Its solubility is good, can be dissolved in a variety of organic solvents.
Use:
5-Cyano-2-methylpyridine is widely used in organic synthesis. It is often used as a catalyst and intermediate in organic reactions. It participates in the chemical transformation of functional groups such as aniline, aldehydes and ketones, and is used in the preparation of pyridine derivatives, heterocyclic compounds and biologically active compounds.
Method:
There are many preparation methods for 5-cyano-2-methylpyrridine, such:
1.2-methyl pyridine reacts with Cyanogen bromide to generate 2-methyl -5-bromopyridine, and then reacts with copper tetrachloride to generate 2-methyl -5-chloropyridine. Finally, it is reacted with hydrocyanic acid to obtain the target product 5-cyano-2-methylpyrridine.
2. Can also be carried out by the oxidation reaction of 2-methyl pyridine to obtain 2-methyl -5-hydroxyl pyridine, and then its reaction with sodium cyanide, and then get 5-cyano-2-methylpyrridine.
Safety Information:
5-cyano-2-methylpyrridine is toxic and should be avoided in contact with skin and eyes. When in use, should take appropriate protective measures, such as wear gloves, safety glasses and protective clothing. In addition, it should be used in a well-ventilated environment to avoid its vapor inhalation. When accidentally ingested or inhaled, the need for timely medical treatment.
Nature:
5-cyano-2-methylpyrridine is an organic compound with pyridine structure, which is colorless to light yellow liquid in appearance. It has a melting point of -29°C and a boiling point of 184-185°C. Its solubility is good, can be dissolved in a variety of organic solvents.
Use:
5-Cyano-2-methylpyridine is widely used in organic synthesis. It is often used as a catalyst and intermediate in organic reactions. It participates in the chemical transformation of functional groups such as aniline, aldehydes and ketones, and is used in the preparation of pyridine derivatives, heterocyclic compounds and biologically active compounds.
Method:
There are many preparation methods for 5-cyano-2-methylpyrridine, such:
1.2-methyl pyridine reacts with Cyanogen bromide to generate 2-methyl -5-bromopyridine, and then reacts with copper tetrachloride to generate 2-methyl -5-chloropyridine. Finally, it is reacted with hydrocyanic acid to obtain the target product 5-cyano-2-methylpyrridine.
2. Can also be carried out by the oxidation reaction of 2-methyl pyridine to obtain 2-methyl -5-hydroxyl pyridine, and then its reaction with sodium cyanide, and then get 5-cyano-2-methylpyrridine.
Safety Information:
5-cyano-2-methylpyrridine is toxic and should be avoided in contact with skin and eyes. When in use, should take appropriate protective measures, such as wear gloves, safety glasses and protective clothing. In addition, it should be used in a well-ventilated environment to avoid its vapor inhalation. When accidentally ingested or inhaled, the need for timely medical treatment.
Last Update：2024-04-10 22:29:15
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View History
6-METHYLNICOTINONITRILE
(5-CHLOROTHIEN-2-YL)METHYLAMINE
Methyl 2,6-dimethoxy-3-nitrobenzoate
Di(4-pyridinyl) sulfide
ESTRIOL 16Α-(Β-D-GLUCURONIDE) SODIUM SALT
4,6-Bis(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine
2-恶唑-7-氮杂螺[3,5]壬烷-7-羧酸-1,1-二甲基乙酯
(R)-1-[(R)-1-(二叔丁基膦基)乙基]-2-[2-(二苯基膦基)苯基]二茂铁
1-Hexanone, 1-(2,4-dichlorophenyl)-2-hydroxy-2-(1H-1,2,4-triazol-1-ylmethyl)-, ethanedioate (1:1)
3-CYANO-4-ISOPROPOXYBENZOIC ACI
(5-CHLOROTHIEN-2-YL)METHYLAMINE
Methyl 2,6-dimethoxy-3-nitrobenzoate
Di(4-pyridinyl) sulfide
ESTRIOL 16Α-(Β-D-GLUCURONIDE) SODIUM SALT
4,6-Bis(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine
2-恶唑-7-氮杂螺[3,5]壬烷-7-羧酸-1,1-二甲基乙酯
(R)-1-[(R)-1-(二叔丁基膦基)乙基]-2-[2-(二苯基膦基)苯基]二茂铁
1-Hexanone, 1-(2,4-dichlorophenyl)-2-hydroxy-2-(1H-1,2,4-triazol-1-ylmethyl)-, ethanedioate (1:1)
3-CYANO-4-ISOPROPOXYBENZOIC ACI