6-Chloro-2-N-ethyl-4-methyl-4-phenyl-4H-3,1-benzoxazin-2-aminehydrochloride
Etifoxine Hydrochloride
CAS: 56776-32-0
Molecular Formula: C17H18Cl2N2O
6-Chloro-2-N-ethyl-4-methyl-4-phenyl-4H-3,1-benzoxazin-2-aminehydrochloride - Names and Identifiers
6-Chloro-2-N-ethyl-4-methyl-4-phenyl-4H-3,1-benzoxazin-2-aminehydrochloride - Physico-chemical Properties
| Molecular Formula | C17H18Cl2N2O |
| Molar Mass | 337.24362 |
| Melting Point | ND |
| Solubility | DMSO: ≥5mg/mL |
| Appearance | powder |
| Color | white to beige |
| Storage Condition | -20°C |
| In vitro study | Etifoxine (EFX), at concentrations ranging from 10 to 300 μM (higher concentrations limited its solubility), produces a dose-dependent increase in the [3H]muscimol binding at equilibrium, to 155±2% of its control value at 300 μM EFX. |
| In vivo study | Etifoxine competitively inhibits [ 35 S]TBPS binding with micromolar potency in rat brain. Etifoxine (3.125-50 mg/kg) exhibits more pronounced anxiolytic and anticonvulsant effects in the BALB/cByJ mice compared to the C57BL/6J mice. Animal Model: Six-week old BALB/cByJ and C57BL/6J mice (20-25 g). Dosage: 3.125-50 mg/kg. Administration: Intraperitoneal inhection. Result: Significantly increased the amount of time spent on the open arms at the 12.5 mg/kg dose when compared to vehicle (p = 0.009) in BALB/cByJ mice but produced no effect in C57B/6J mice. BALB/cByJ mice compared with C57BL/6J mice exhibited significantly (p < 0.012) lower plasma levels of the compound at 15 and 30 min. |
6-Chloro-2-N-ethyl-4-methyl-4-phenyl-4H-3,1-benzoxazin-2-aminehydrochloride - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
| WGK Germany | 3 |
6-Chloro-2-N-ethyl-4-methyl-4-phenyl-4H-3,1-benzoxazin-2-aminehydrochloride - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.965 ml | 14.826 ml | 29.652 ml |
| 5 mM | 0.593 ml | 2.965 ml | 5.93 ml |
| 10 mM | 0.297 ml | 1.483 ml | 2.965 ml |
| 5 mM | 0.059 ml | 0.297 ml | 0.593 ml |
Last Update：2024-01-02 23:10:35
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