Molecular Formula | C6H7N3O |
Molar Mass | 137.14 |
Density | 1.2620 (rough estimate) |
Melting Point | 245-248 °C (lit.) |
Boling Point | 251.97°C (rough estimate) |
Flash Point | 184.6°C |
Water Solubility | Soluble in Dimethyl sulfoxide (DMSO). Insoluble in water. |
Vapor Presure | 5E-06mmHg at 25°C |
Appearance | powder to crystal |
Color | White to Light yellow |
BRN | 116042 |
pKa | 15.66±0.50(Predicted) |
Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
Refractive Index | 1.6910 (estimate) |
In vitro study | 6-Aminonicotinamide (100 nM; 7 days) causes a significant decrease in the human AR+, hormone-sensitive prostate cancer cell lines LNCaP and LAPC4, as well as the CRPC-derivative C4-2 and 22Rv1 cell models. 6-Aminonicotinamide (100 nM ± 10 nM R1881 as indicated for 3 days) increases both basal- and R1881-mediated ROS levels, suggesting 6-Aminonicotinamide is blocking the cells' antioxidant defense. 6-Aminonicotinamide also increases ROS levels in C4-2 cells. |
In vivo study | 6-Aminonicotinamide (20 mg/kg; i.p.; thress times; days 1, 10 or 11, and 21) alone induces a small but significant tumor growth delay (4.3+/-0.8 days). Treatment with 6-Aminonicotinamide followed by radiation induces a tumor growth delay of 57.0+/-3.8 days in CD8F1 breast tumor model. |
Hazard Symbols | T - Toxic |
Risk Codes | 61 - May cause harm to the unborn child |
Safety Description | S53 - Avoid exposure - obtain special instructions before use. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
UN IDs | 1655 |
WGK Germany | 3 |
RTECS | US4550000 |
HS Code | 29333990 |
Hazard Note | Toxic |
Hazard Class | 6.1 |
Packing Group | II |
NIST chemical information | Information provided by: webbook.nist.gov (external link) |
EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
Biological activity | 6-Aminonicotinamide (6AN) is an antimetabolite that can be used to inhibit NADPH-producing pentose phosphate pathway (PPP) in many cell systems, thereby making It is more susceptible to oxidative stress. 6-Aminonicotinamide is a competitive inhibitor of NADP -dependent enzyme glucose-6-phosphate dehydrogenase (G6PD) with a Ki value of 0.46 μM. |
Target | Value |
G6PD (Cell-free assay) | 0.46 μM(Ki) |
category | pesticide |
toxicity classification | highly toxic |
acute toxicity | abdominal cavity-rat LD50: 11 mg/kg; Oral administration-mouse LDL0: 320 mg/kg |
flammability hazard characteristics | combustible; combustion produces toxic nitrogen oxide smoke |
storage and transportation characteristics | warehouse ventilation and low temperature drying |
fire extinguishing agent | dry powder, foam, sand, carbon dioxide, mist water |