6-Amino-5-nitro-4-(ribofuranosylamino)pyrimidine
Clitocine
CAS: 105798-74-1
Molecular Formula: C9H13N5O6
6-Amino-5-nitro-4-(ribofuranosylamino)pyrimidine - Names and Identifiers
6-Amino-5-nitro-4-(ribofuranosylamino)pyrimidine - Physico-chemical Properties
| Molecular Formula | C9H13N5O6 |
| Molar Mass | 287.231 |
| Appearance | Solid |
| Storage Condition | 2-8°C，密封，干燥 |
| In vitro study | Clitocine incorporation into mRNA is required for premature stop codon readthrough activity, and the presence of clitocine at the third position of a premature stop codon is sufficient to promote robust readthrough. Clitocine (0-0.8 μM; 24 hours) enhances TRAIL-lethality in in LS411N and SW620 cells. Clitocine (0.2μM; 36 hours) significantly potentiates TRAIL-mediated apoptosis. |
6-Amino-5-nitro-4-(ribofuranosylamino)pyrimidine - Reference Information
| biological activity | Clitocine is an adenosine nucleoside analog derived from mushrooms and is an effective reading through. Clitocine, an inhibitor of nonsense mutations, induces p53 protein production in cells carrying the p53 nonsense mutant allele. Clitocine can induce apoptosis of multidrug-resistant tumor cells by targeting Mcl-1. Has anti-cancer activity. |
| Animal Model: | nu/nu mice (CAOV-3p53-UAA136 xenograft tumors) |
| Dosage: | 0.3, 3 mg/kg (or 20 mg/kg once per week) |
| Administration: | S.c.; five times per week |
| Result: | CAOV-33 p53-UAA136 tumor growth was inhibited. |
Last Update：2024-04-10 22:29:15
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Multiple SpecificationsSpot supply
Product Name: Clitocine Visit Supplier Webpage Request for quotationCAS: 105798-74-1
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: Clitocine Visit Supplier Webpage Request for quotationCAS: 105798-74-1
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: Clitocine Visit Supplier Webpage Request for quotationCAS: 105798-74-1
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
View History
6-Amino-5-nitro-4-(ribofuranosylamino)pyrimidine
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105946-82-5
2-fluoro-3-keto-succinic acid
2-amino-8-(4-bromobenzylidene)-4-(4-bromophenyl)-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile
Ethanone, 2-(1,3-benzodioxol-5-yl)-1-(2-benzothiazolyl)-
13504-89-7
2-Aminoterephthalic Acid Dimethyl Ester
4-chloro-N-(4-methyl-1,3-thiazol-2-yl)butanamide
5-(S-2-Phenyl-pyrrolidine)-1-yl-5-deoxy-1,2-isopropylidene-a-D-xylofuranose
883514-21-4