6-氯哒嗪-3-羧基 酸
6-Chloropyridazine-3-carboxylic acid
CAS: 5096-73-1
Molecular Formula: C5H3ClN2O2
6-氯哒嗪-3-羧基 酸 - Names and Identifiers
6-氯哒嗪-3-羧基 酸 - Physico-chemical Properties
| Molecular Formula | C5H3ClN2O2 |
| Molar Mass | 158.54 |
| Density | 1.579±0.06 g/cm3(Predicted) |
| Melting Point | 146 °C |
| Boling Point | 429.0±25.0 °C(Predicted) |
| Flash Point | 213.245°C |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | White powder |
| Color | White to cream |
| pKa | 2.68±0.10(Predicted) |
| Storage Condition | Inert atmosphere,Room Temperature |
| Refractive Index | 1.598 |
| MDL | MFCD00160464 |
6-氯哒嗪-3-羧基 酸 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| HS Code | 29339980 |
| Hazard Class | IRRITANT |
6-氯哒嗪-3-羧基 酸 - Reference Information
| Properties | 6-chlorpyridine-3-carboxylic acid is white crystal powder at room temperature and pressure. |
| Use | 6-chlorpyridine-3-carboxylic acid can be used as a small molecule intermediate in pharmaceutical chemistry and pesticides. In the synthesis and transformation, it mainly revolves around the structure Carboxyl group, the carboxyl group can undergo esterification reaction, reduction reaction, and acyl chlorination reaction without being affected by the two nitrogen atoms in the pyridazine molecule. |
| synthesis method | add 3-chloro -6-methylpyridazine (155.6 mmol) solution in 140 mL concentrated sulfuric acid to the vacuum dry reaction bottle, and then slowly add fine powdered potassium dichromate (55.40 g) under stirring, carefully detect the reaction temperature to ensure that the temperature remains below 50°C. When the addition is completed, continue stirring at 50°C for another 4 hours. Then cool the obtained viscous dark green liquid and carefully add crushed ice, extract the reaction mixture with ethyl acetate (6 x400mL), stratify the mixture, separate the organic layer, and combine the separated ethyl acetate extract, Dry with anhydrous sodium sulfate, filter to remove the sodium sulfate solid, vacuum concentration to remove the organic solvent to obtain the target molecule 6-chlorpyridine-3-carboxylic acid, which is light red, yield 106.6 mmol 69%. Figure 6-Chlorpyridine-3-carboxylic acid synthesis route |
Last Update：2024-04-09 21:21:28
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View History
6-氯哒嗪-3-羧基 酸
4-苯并[B]噻吩-4-基-1-哌嗪甲酸1,1-二甲基乙酯
5-羟基吡唑-3-羧酸乙酯
4-碘苯磺酰氯(对碘苯磺酰氯)
D-3-溴樟脑-10-磺酸.一水合物
(3,5-二(三氟甲基)苯乙炔基)三甲基硅烷
2-(6-氧代-3-噻吩-2-基哒嗪-1-基)乙酸
2-庚基环戊酮
2-溴-4-碘代苯甲酸甲酯
[2H7]-1-萘甲酸[干冰运输,需加收额外费用]
4-苯并[B]噻吩-4-基-1-哌嗪甲酸1,1-二甲基乙酯
5-羟基吡唑-3-羧酸乙酯
4-碘苯磺酰氯(对碘苯磺酰氯)
D-3-溴樟脑-10-磺酸.一水合物
(3,5-二(三氟甲基)苯乙炔基)三甲基硅烷
2-(6-氧代-3-噻吩-2-基哒嗪-1-基)乙酸
2-庚基环戊酮
2-溴-4-碘代苯甲酸甲酯
[2H7]-1-萘甲酸[干冰运输,需加收额外费用]