Molecular Formula | C27H44O3 |
Molar Mass | 416.64 |
Density | 1.0362 (rough estimate) |
Melting Point | ~185°C |
Boling Point | 474.91°C (rough estimate) |
Specific Rotation(α) | D25 -69° (c = 0.5 in chloroform) |
pKa | 15.14±0.70(Predicted) |
Storage Condition | RT, dark |
Refractive Index | 1.4700 (estimate) |
WGK Germany | 3 |
FLUKA BRAND F CODES | 10 |
biological activity | Smilagenin (SMI) is a small, from anemarrhenae and geranium Radix asparagi, it is widely used in the study of chronic neurodegenerative diseases. Smilagenin (SMI) improves memory in aged rats by increasing the density of muscarinic receptor subtype 1 (M1)-receptors. Smilagenin (SMI) attenuates Aβ (25-35)-induced neurodegeneration by stimulating brain-derived neurotrophic factor gene expression and is useful in AD studies. |
Cell Line: | SH-SY5Y cells SH-SY5Y cells |
Concentration: | 10 μM 10 μM |
Incubation Time: | 24 hours 24 hours |
Result: | Elevated the SH-SY5Y cell viability. Increased GDNF and BDNF transcription. Ameliorated locomotor ability of MPTP/probenecid-lesioned mice. |
Animal Model: | MPTP/probenecid-induced mouse model |
Dosage: | 10 or 26 mg/kg |
Administration: | Intragastric administration; 10 or 26 mg/kg; once daily; 60 days |