Molecular Formula | C18H23ClN2 |
Molar Mass | 302.84 |
Melting Point | 214-2160C |
Flash Point | 11°C |
Solubility | H2O: 50mg/mL |
Appearance | powder |
Color | white to off-white |
Storage Condition | 2-8°C |
In vivo study | Treatment of rats with Desipramine hydrochloride for 14 days reduces norepinephrine transporter (NET) expression in a dose-dependent manner, as indicated by a reduction of the specific binding of 3 H-nisoxetine to the NET in preparations of cerebral cortex (F (3,16) =4.33, p<0.05) and hippocampus (F (3,16) =4.34, p<0.05). This NET down regulation is observed 2 days after discontinuation of chronic Desipramine hydrochloride treatment, a time when plasma and brain concentrations of Desipramine hydrochloride and desmethyldesipramine are undetectable (ie below the 25 ng detection limit of the assay). |
Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. R42/43 - May cause sensitization by inhalation and skin contact. R48/23/24/25 - R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R11 - Highly Flammable R39/23/24/25 - |
Safety Description | S7 - Keep container tightly closed. S16 - Keep away from sources of ignition. S36/37 - Wear suitable protective clothing and gloves. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S24 - Avoid contact with skin. S22 - Do not breathe dust. |
UN IDs | UN 1230 3/PG 2 |
WGK Germany | 3 |
RTECS | HO0525000 |
HS Code | 2933996100 |
Toxicity | LD50 in mice, rats (mg/kg): 500, 385 orally; 94, 48 i.p.; 420, 183 s.c. (Eriksoo, Rohte) |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 3.302 ml | 16.51 ml | 33.02 ml |
5 mM | 0.66 ml | 3.302 ml | 6.604 ml |
10 mM | 0.33 ml | 1.651 ml | 3.302 ml |
5 mM | 0.066 ml | 0.33 ml | 0.66 ml |