572-31-6
Engeletin
CAS: 572-31-6
Molecular Formula: C21H22O10
572-31-6 - Names and Identifiers
572-31-6 - Physico-chemical Properties
| Molecular Formula | C21H22O10 |
| Molar Mass | 434.39 |
| Density | 1.66 |
| Melting Point | 176-177℃ |
| Boling Point | 763.4±60.0 °C(Predicted) |
| Specific Rotation(α) | (Me2CO)-16 |
| Solubility | Soluble in boiling water, soluble in DMSO, hot methanol, almost insoluble in ether. |
| Appearance | White crystal |
| pKa | 7.37±0.60(Predicted) |
| Storage Condition | 2-8℃ |
| MDL | MFCD01632717 |
| Physical and Chemical Properties | White-like crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Smilax glabra. Smilax. |
| In vitro study | Engeletin is a flavanonol glycoside isolated from hymenaea martiana , inhibits NF-κB signaling-pathway activation. |
| In vivo study | Engeletin (25, 50, 100 mg/kg, i.p.) markedly reduces LPS-increased myeloperoxidase activity in mice, activates NF-κB-pathway activation, decreases the production of inflammatory mediators (iNOS and COX-2), and suppresses the expression of TLR4-signaling downstream molecules such as MyD88, IRAK1, TRAF6, and TAK1 proteins. |
572-31-6 - Risk and Safety
| HS Code | 29389090 |
572-31-6 - Reference
| Reference Show more | 1. Liu Lijuan, Zhao Ruizhi, Lu Chuanjian. Study on anti-psoriasis compatibility law of No. 2 prescription of yinxieling optimized prescription based on efficacy-component analysis [J]. Chinese Journal of Traditional Chinese Medicine, 2020,35(08):4171-4174. 2. Wang Mengxue, Dai Hanpeng, Li Jinming, Su Ya, Han Xinran, Li Li. Inhibition of CYP3A4 activity by Smilax glabra [J]. Journal of Changchun Normal University, 2020,39(08):60-63. 3. Guo Yang, Xin Zhao, Jun Wen, quantitative analysis and anti-oxidant based screening of components in rhezoma Smilacis Glabrae using liquid chromatography coupled with Charged Aerosol and coumetric 4. [IF = 4.192] Haichong Wu et al."Engeletin Alleviates Lipopolysaccharide-Induced Endometritis in Mice by Inhibiting TLR4-mediated NF-κB Activation."J Agr Food Chem. 2016;64(31):6171-6178 5. [IF=3.645] Weiquan Dai et al."Simultaneous chemical fingerprint and quantitative analysis of Rhizoma Smilacis Glabrae by accelerated solvent extraction and high-performance liquid chromatography with tandem mass spectrometry."J Sep Sci. 2015 May;38(9):1466-1475 6. [IF=4.098] Yangyang Fan et al."Interaction study of engeletin toward cytochrome P450 3A4 and 2D6 by multi-spectroscopy and molecular docking."Spectrochim Acta A. 2022 Jan;264:120311 |
572-31-6 - Reference Information
| biological activity | Engeletin is a flavonoid glycoside derived from hymenaea Mariana, which can inhibit the activation of NF-κB signaling pathway, has anti-inflammatory, analgesic, diuretic, swelling, antibacterial effect. |
| Target | Value |
| Use | Huangqi glycoside has the function of promoting blood circulation to remove blood stasis, lowering blood lipid and lowering blood pressure. for content determination/identification/pharmacological experiments. Pharmacological Efficacy: has a strong diuretic and analgesic effect. |
Last Update：2024-04-09 21:54:55
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View History
572-31-6
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175204-11-2
312-22-1
5,12-dihydro-5,12-bis(phenylethynyl)naphthacene-5,12-diol
Calmagite
3-butyl-6-(4-fluorophenyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
1807505-29-8
1,2-Benzenedicarboxamide, N1,N2-bis(1-oxo-1H-phenalen-2-yl)-
66248-70-2
5-oxoprolylhistidyl-N-[18,18-diamino-7-(tert-butoxymethyl)-13-({2-[(2-carbamoylhydrazinyl)carbonyl]pyrrolidin-1-yl}carbonyl)-4-(4-hydroxybenzyl)-1-(hydroxymethyl)-10-(2-methylpropyl)-2,5,8,11-tetraoxo-3,6,9,12,17-pentaazaoctadec-17-en-1-yl]tryptophanamide