52090-89-8 - Names and Identifiers
Name | 5-chloro-1H-imidazo[4,5-b]pyridine
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Synonyms | 5-Chloro-3H-imidazo[4,5-b... 5-chloro-1H-imidazo[4,5-b]pyridine 5-chloro-3H-imidazo[4,5-b]pyridine 5-CHLORO-3H-IMIDAZO[4,5-B]PYRIDINE 3H-imidazo[4,5-b]pyridine, 5-chloro- 3H-IMidazo[4,5-b]pyridine, 5-chloro- 5-chloro-1(3)H-imidazo[4,5-b]pyridine
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CAS | 52090-89-8
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EINECS | 1592732-453-0 |
InChI | InChI=1/C6H4ClN3/c7-5-2-1-4-6(10-5)9-3-8-4/h1-3H,(H,8,9,10) |
52090-89-8 - Physico-chemical Properties
Molecular Formula | C6H4ClN3
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Molar Mass | 153.57 |
Density | 1.61±0.1 g/cm3(Predicted) |
Melting Point | 230-232 °C |
Boling Point | 262.4±50.0 °C(Predicted) |
Flash Point | 237.3°C |
Vapor Presure | 1.02E-06mmHg at 25°C |
pKa | 7.53±0.40(Predicted) |
Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
Refractive Index | 1.72 |
52090-89-8 - Introduction
5-chloro-1H-imidazo[4,5-b]pyridine is an organic compound with the chemical formula C7H4ClN3. Here are some information about its nature, use, formulation and safety:
Nature:
-Appearance: Colorless to light yellow crystal
-Melting point: 137-140°C
-Boiling point: 395.8°C
-Soluble: Soluble in chloroform, acetone and dimethylthionamide, slightly soluble in alcohol and ether
Use:
- 5-chloro-1H-imidazo[4,5-b]pyridine can be used as an intermediate in organic synthesis.
-It is also commonly used in the pharmaceutical field as a raw material for the preparation of anti-cancer drugs.
Preparation Method:
5-chloro-1H-imidazo[4,5-b]pyridine can be prepared by a variety of methods, one of which is commonly used by the reaction of imidazole and 3-chloropyridine. Specific steps include:
1. Imidazole is added to the solution containing alcohol or ether.
2. Cool to low temperature and add 3-chloropyridine.
3. Stir the reaction at an appropriate temperature. After the reaction is completed, remove the solvent to obtain the product.
Safety Information:
- 5-chloro-1H-imidazo[4,5-b]pyridine may have a certain degree of irritation, please avoid contact with skin and eyes.
-During use and storage, please be careful to avoid ignition and avoid inhalation or intake.
-Wear personal protective equipment such as lab gloves and goggles when using.
-In case of contact with skin or eyes, wash with plenty of water and seek medical help immediately.
Please note that this is only a general description of the 5-chloro-1H-imidazo[4,5-b]pyridine and that the specific nature, use, formulation and safety information may require further understanding and validation on a case-by-case basis. If you need to use this compound, please be sure to refer to the relevant literature and product instructions, and follow the correct safe operating procedures.
Last Update:2024-04-09 15:17:58