Name | 4-Bromo-2,6-dimethylpyridine |
Synonyms | 4-Bromo-2,6-lutidine 2.6-Dimethyl-4-bromopyridine 4-Bromo-2,6-dimethylpyridine 4-Bromo-2,6-dimethyl-pyridine pyridine, 4-bromo-2,6-dimethyl- Pyridine, 4-broMo-2,6-diMethyl- 4-bromo-2,6-dimethylpyridine hydrobromide |
CAS | 5093-70-9 |
InChI | InChI=1/C7H8BrN/c1-5-3-7(8)4-6(2)9-5/h3-4H,1-2H3 |
Molecular Formula | C7H8BrN |
Molar Mass | 186.05 |
Density | 1.415±0.06 g/cm3(Predicted) |
Melting Point | 28-32°C |
Boling Point | 194 °C |
Flash Point | 93℃ |
Vapor Presure | 0.327mmHg at 25°C |
pKa | 5.41±0.10(Predicted) |
Storage Condition | 2-8°C |
Refractive Index | 1.547 |
MDL | MFCD00671475 |
Hazard Symbols | Xn - Harmful |
Risk Codes | R22 - Harmful if swallowed R41 - Risk of serious damage to eyes R37/38 - Irritating to respiratory system and skin. |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S39 - Wear eye / face protection. S24/25 - Avoid contact with skin and eyes. |
WGK Germany | 3 |
HS Code | 29349990 |
use | 4-bromo-2, 6-dimethylpyridine and its homologs are found in bone tar, coal tar, coal gas, shale oil, petroleum. 4-Bromo-2, 6-dimethylpyridine can be used as a raw material for the synthesis of a series of products (including pharmaceuticals, disinfectants, dyes, etc.) in the industry. |
Synthesis method | 2, 6-dimethylpyridine-4-ol (3.25g) in chloroform (40 mL) was treated with phosphorus pentabromide (11.5g). The reaction was heated to 60°C for 2 hours and the solvent was removed. The residue was heated to 120°C overnight. The reaction mixture was treated with NaOH(45g dissolved in 500 mL of water) and the product was extracted into EtOAc(3 x 100 mL). The bound organic matter was dried on sodium sulfate and concentrated onto diatomaceous earth. The product 4-bromo-2, 6-dimethylpyridine was purified by silica gel chromatography using EtOAc in hexane (0-35%). Yellow oil with a yield of 2.95 grams. Figure 4-Bromo-2, 6-dimethylpyridine synthesis route |
Health hazards | 4-bromo -2, 6-dimethylpyridine has strong irritation; it can anesthetize the central nervous system. It has a stimulating effect on the eyes and upper respiratory tract. After high concentration inhalation, the light has a sense of euphoria or suffocation, followed by depression, muscle weakness, vomiting; severe loss of consciousness, incontinence, tonic spasm, blood pressure drop. Mistakes can kill you. |