Fmoc-S-3-Amino-3-(3-hydroxy-phenyl)-propionic acid is an organic compound with the following properties:
1. Appearance: A white or off-white crystalline powder.
2. molecular formula: C21H17NO4S.
3. Molecular weight: 383.43g/mol.
4. Solubility: Slightly soluble in ethanol and ether, insoluble in water.
5. Melting point: about 155-158 degrees Celsius.
Fmoc-S-3-Amino-3-(3-hydroxy-phenyl)-propionic acid is mainly used as a protecting group in solid-phase synthesis to attach it to the amino-terminal small molecule or polypeptide. It can be used to synthesize polypeptides, proteins or drug molecules with specific biological activities.
In terms of preparation, a common method is to first synthesize Fmoc-L-tyrosine anhydride, then react with sodium sulfate to form Fmoc-S-tyrosine anhydride, and then react with 3-hydroxyphenylpropionaldehyde to form Fmoc-S-3-amino -3-(3-hydroxyphenyl) propionic acid.
Safety precautions are required when using Fmoc-S-3-Amino-3-(3-hydroxy-phenyl)-propionic acid. It is a chemical and should follow laboratory safety procedures and be equipped with personal protective equipment such as gloves and goggles. Avoid contact with skin and eyes, and avoid inhalation or swallowing. If any skin contact or inhalation occurs, rinse immediately with plenty of water and seek medical help. Be sure to store and use in a well-ventilated location.