5-氯-2-羟基苯基硼酸

5-氯-2-羟基苯基硼酸 - Names and Identifiers

Name	(5-chloro-2-hydroxyphenyl)boronic acid
Synonyms	AKOS BRN-0742 2-Borono-4-chlorophenol 5-CHLORO-2-HYDROXYPHENYLBORONIC ACID 5-Chloro-2-hydroxyphenylboronic acid 5-CHLORO-2-HYDROXYBENZENEBORONIC ACID (5-Chloro-2-hydroxyphenyl)boronic acid (5-chloro-2-hydroxyphenyl)boronic acid Benzeneboronic acid, 5-chloro-2-hydroxy- Boronic acid, B-(5-chloro-2-hydroxyphenyl)-
CAS	89488-25-5
InChI	InChI=1/C6H6BClO3/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,9-11H

5-氯-2-羟基苯基硼酸 - Physico-chemical Properties

Molecular Formula	C6H6BClO3
Molar Mass	172.37
Density	1.49±0.1 g/cm3(Predicted)
Melting Point	166-170
Boling Point	369.3±52.0 °C(Predicted)
Flash Point	177.131°C
Vapor Presure	0mmHg at 25°C
pKa	7.63±0.58(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
Refractive Index	1.602

5-氯-2-羟基苯基硼酸 - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	41 - Risk of serious damage to eyes
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S39 - Wear eye / face protection.
Hazard Note	Irritant

5-氯-2-羟基苯基硼酸 - Reference Information

Introduction

5-chloro-2-hydroxyphenylboronic acid is an organic intermediate, it is reported in the literature that it can be obtained by using 5-chloro-2-methoxyphenyl boronic acid as a raw material and removing methyl.

preparation

5-chloro-2-methoxyphenylboronic acid (10.0g,53.6mmol) in dichloromethane (100ml) the solution was cooled to a temperature of 5-10 °c. 100ml of

1m boron tribromide solution in DCM was added dropwise to the above mixture over a period of 30 minutes using a pressure-equalizing dropping funnel. The resulting reaction mixture was then stirred at room temperature for 30 minutes. After completion of the reaction, the mixture was poured Dropwise into ice-cold saturated sodium bicarbonate solution (600ml). The resulting mixture was allowed to stir at room temperature for 1 hour. The DCM layer was separated and the aqueous layer thus collected was cooled to a temperature of 10-15 °c. A 1N dilute hydrochloric acid solution was then added to the cooled aqueous layer as described above, and this resulted in the formation of a precipitate. The solid was filtered off under vacuum and dried to afford 9G (97% yield) of product.

Last Update：2024-04-10 22:29:15