5-isocyanato-2,3-dihydrobenzofuran - Names and Identifiers
Name | 5-isocyanato-2,3-dihydrobenzofuran
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Synonyms | 5-isocyanato-2,3-dihydrobenzofuran 5-Isocyanato-2,3-dihydrobenzofuran Benzofuran, 2,3-dihydro-5-isocyanato- 5-Isocyanato-2,3-dihydro-1-benzofuran 2,3-DIHYDROBENZO[B]FURAN-5-ISOCYANATE 1,2-Dihydrobenzo[b]furan-5-isocyanate 2,3-dihydrobenzo[b]furan-5-yl isocyanate 2,3-DIHYDRO-1-BENZOFURAN-5-YL ISOCYANATE 2,3-Dihydro-1-Benzofuran-5-Yl Isocyanate Benzofuran,2,3-dihydro-5-isocyanato-(9CI) 2,3-Dihydro-5-isocyanatobenzo[b]furan, 2,3-Dihydro-5-isocyanato-1-benzofuran
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CAS | 215162-92-8
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InChI | InChI=1/C9H7NO2/c11-6-10-8-1-2-9-7(5-8)3-4-12-9/h1-2,5H,3-4H2 |
5-isocyanato-2,3-dihydrobenzofuran - Physico-chemical Properties
Molecular Formula | C9H7NO2
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Molar Mass | 161.16 |
Density | 1.251g/cm3 |
Melting Point | 42 °C |
Boling Point | 130-132°C 3mm |
Flash Point | 142.541°C |
Solubility | Chloroform (Slightly), Methanol (Slightly) |
Vapor Presure | 0.004mmHg at 25°C |
Appearance | Solid |
Color | White to Off-White Low-Melting |
Storage Condition | Hygroscopic, Refrigerator, under inert atmosphere |
Stability | Hygroscopic, Moisture Sensitive |
Refractive Index | 1.602 |
5-isocyanato-2,3-dihydrobenzofuran - Risk and Safety
Hazard Symbols | Xn - Harmful
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Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed.
R36/37/38 - Irritating to eyes, respiratory system and skin.
R52 - Harmful to aquatic organisms
R22 - Harmful if swallowed
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Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
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UN IDs | 2206 |
Hazard Note | Harmful |
5-isocyanato-2,3-dihydrobenzofuran - Introduction
5-isocyanato-2,3-dihydrobenzofuran(5-isocyanato-2,3-dihydrobenzofuran) is an organic compound. Its chemical formula is C9H7NO2 and its molecular weight is 161.16g/mol. The following is a description of its nature, use, formulation and safety information:
Nature:
-Appearance: 5-isocyanato-2,3-dihydrobenzofuran is a colorless to pale yellow liquid or solid.
-Melting point: About 25-30 ℃.
-Boiling point: about 170-180 ℃.
-Storage conditions: Avoid moisture and direct sunlight.
Use:
- 5-isocyanato-2,3-dihydrobenzofuran is commonly used as an intermediate in organic synthesis.
-It can participate in a variety of reactions, such as the Barr-Mirkanovsky reaction, Michael addition reaction, etc.
-In the pharmaceutical field, it may be used to synthesize specific compounds.
Method:
5-isocyyanato-2, 3-dihydrobenzofuran can be synthesized by the following steps:
1.2,3-dihydrobenzofuran reacts with thionyl chloride to generate 2,3-dihydrofuran -5-one.
2.2,3-dihydrofuran -5-one reacts with chlorocyanate to generate 2,3-dihydrobenzofuran -5-cyanate.
3. React 2,3-dihydrobenzofuran -5-cyanate with a shrinking agent (such as sulfite) to generate 5-isocyyanato-2, 3-dihydrobenzofuran.
Safety Information:
-5-isocyyanato-2, 3-dihydrobenzofuran is irritating and harmful to eyes, skin, etc.
-Wear appropriate personal protective equipment, such as goggles, gloves and lab coats, during use or operation.
-Avoid contact with fire and high temperature.
-During storage and use, it should be stored separately from oxidants and corrosives to avoid accidents.
-Local environmental regulations should be followed when disposing of waste.
Last Update:2024-04-09 02:00:44