5-(trifluoromethyl)thiophen-3-ol is an organic compound with the chemical formula C6H3F3OS. The following is an introduction to some of its properties, uses, methods and safety information:
Nature:
-Appearance: It is a colorless to slightly yellow liquid.
-Melting point: approximately -29°C.
-Boiling point: about 170-174 ℃.
-Density: about 1.512-1.518g/cm³.
-Solubility: It is soluble in common organic solvents such as ethanol and dimethylformamide.
Use:
- 5-(trifluoromethyl)thiophen-3-ol is an important intermediate compound and has a wide range of applications in the field of organic synthesis.
-It can be used to synthesize a series of biologically active compounds, such as drugs, pesticides and functional materials.
-This compound is also used in the research and preparation of organic optoelectronic devices.
Method:
A common preparation method is as follows:
1. First, 3-thiophenol (3-thiophenol) undergoes a substitution reaction with trifluoromethane (trifluoromethyl) under alkaline conditions to produce 5-(trifluoromethyl) thiophene ().
2. The resulting 5-(trifluoromethyl) thiophene is then reacted with sodium hydroxide (NaOH) in an appropriate solvent to give 5-(trifluoromethyl)thiophen-3-ol.
Safety Information:
- 5-(trifluoromethyl)thiophen-3-ol should be operated in a well-ventilated environment to avoid inhalation or skin contact.
-During use, you should wear suitable personal protective equipment, such as goggles and protective gloves.
-If you take it by mistake or enter the eye by mistake, please seek medical assistance immediately and show the safety data of the compound to the doctor.
-Keep the compound well away from ignition and oxidizing agents.