5-Oxo-DL-proline-d5 - Names and Identifiers
5-Oxo-DL-proline-d5 - Physico-chemical Properties
Molecular Formula | C5H7NO3
|
Molar Mass | 129.12 |
Melting Point | 175 - 177°C |
Solubility | DMSO (Slightly), Methanol (Slightly) |
Appearance | Solid |
Color | White to Off-White |
Storage Condition | Refrigerator |
5-Oxo-DL-proline-d5 - Introduction
5-Oxo-DL-proline-d5 (5-Oxo-DL-proline-d5) is a labeled compound with the following properties:
-molecular formula: C5H3D5NO3
-relative molecular mass: 129.17g/mol
-Appearance: White crystal or crystalline powder
-Melting point: 163-166 ° C
-Soluble: Soluble in water and ethanol
5-Oxo-DL-proline-d5 is commonly used as a labeling reagent in nuclear magnetic resonance (NMR) research to label and track the reaction and metabolism of compounds in biological systems. Due to its stable isotope labeling (embedding of heavy Hydrin D) and clear response in NMR spectrum, 5-Oxo-DL-proline-d5 is widely used in drug research and development, biochemistry, metabolomics and other fields.
The preparation method of 5-Oxo-DL-proline-d5 can be synthesized from natural products or synthetic compounds. A common preparation method is as follows:
1. First, select an appropriate starting compound, such as L-glutamic acid (L-Glutamic acid).
2. In a suitable solvent, the starting compound and heavy water reagent reaction. Common heavy hydrating reagents include heavy water or sodium deuterium oxide (D2O/NaOD).
3. Adjust the reaction conditions, such as temperature and reaction time, to convert the compound into 5-oxo-d1-proline-d5.
4. Finally, the target product is purified and harvested through the steps of crystallization, washing and drying.
In terms of safety, 5-Oxo-DL-proline-d5 has not been reported to be toxic or fatal. However, as an organic compound, normal laboratory safety practices should generally be followed, including wearing appropriate personal protective equipment (such as gloves, goggles, etc.) to avoid contact with skin and eyes, avoid inhalation or ingestion. In case of accidental splashing or contact, rinse immediately with plenty of water. In case of doubt or emergency, seek medical help immediately, consult the relevant agencies and follow the safe operation guidelines.
Last Update:2024-04-09 21:01:54