Name | 5-Bromo-2,3-diaminopyridine |
Synonyms | AKOS AUF02002 AKOS BBS-00000089 IFLAB-BB F2124-0011 LABOTEST-BB LT00000360 5-BROMO-2,3-DIAMINOPYRIDINE 5-Bromo-2,3-diaminopyridine 2,3-DIAMINO-5-BROMOPYRIDINE 5-Bromopyridine-2,3-diamine 5-BROMOPYRIDINE-2,3-DIAMINE 2,3-Diamino-5-bromopyridine 2,3-diamino-5-bromopyridinium |
CAS | 38875-53-5 |
EINECS | 254-172-9 |
InChI | InChI=1/C5H6BrN3/c6-3-1-4(7)5(8)9-2-3/h1-2H,7H2,(H2,8,9)/p+1 |
InChIKey | YRGMYJUKFJPNPD-UHFFFAOYSA-N |
Molecular Formula | C5H6BrN3 |
Molar Mass | 188.03 |
Density | 1.6770 (rough estimate) |
Melting Point | 155 °C (dec.) (lit.) |
Boling Point | 180 °C(Press: 0.005-0.01 Torr) |
Flash Point | 147.9°C |
Water Solubility | soluble in hot water |
Solubility | soluble in Methanol |
Vapor Presure | 0.000308mmHg at 25°C |
Appearance | Bright brown powder |
Color | Light yellow to purple or light brown |
BRN | 119436 |
pKa | 4.53±0.49(Predicted) |
Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
Sensitive | Nitrogen filled storage |
Refractive Index | 1.6400 (estimate) |
MDL | MFCD00460094 |
Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R34 - Causes burns |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S37/39 - Wear suitable gloves and eye/face protection S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
WGK Germany | 3 |
HS Code | 29333990 |
Hazard Note | Irritant |
Hazard Class | 6.1 |
Packing Group | III |
Reference Show more | 1. [IF=10.588] Xiang Zhang et al."Blue/yellow emissive carbon dots coupled with curcumin: a hybrid sensor toward fluorescence turn-on detection of fluoride ion."J Hazard Mater. 2021 Jun;411:125184 |
introduction | 2,3-diamino -5-bromopyridine is light yellow to purple or light brown powder, density: 1.818 g/cm3, boiling point: 321°C, melting point: 155°C (dec.)(lit.), it is an important intermediate for preparing many medicines and pesticides, it is used in the pharmaceutical industry to synthesize heart disease drugs such as disopyramide (disopyramide phosphate). |
Uses | The molecular structure of 2,3-diamino-5-bromopyridine contains multiple reaction sites such as bromine and amino groups, which can be modified in a variety of structures., As an active intermediate of a variety of medicines. |
synthesis method | 2-amino -3-nitro -5-bromopyridine (15.0g,0.075 mol) is dissolved in a mixed solution of hot phosphoric acid and ethanol (100 mL,V/V = 20/80), and cooled to 25 ℃. Saturated hydrogen chloride ethanol solution (135 mL), concentrated hydrochloric acid (15 mL) and 10% Raney-Ni(1.5g) were added sequentially. Pour the above mixture into 500 mL autoclave, and then adjust the pressure to 1 MPa; The temperature is increased and the temperature is controlled at about 50 ℃. When the pressure no longer drops, it indicates that the reaction has ended, cooling, discharging, filtering, and washing the filter cake with 50 mL ethanol. Then pour the filtrate into a mixed solution of tetrahydrofuran (THF) and concentrated hydrochloric acid (300 mL,V/V = 5/1), seal it and place it in a refrigerator overnight, spin the solvent, filter, and vacuum dry to obtain 16.5g of yellow solid 2,3-diamino-5-bromopyridine with a yield of 89%. |