5-(trifluoromethyl)-1H-Pyrazol-3-amine is an organic compound with the chemical formula C4H3F3N4. The following is an introduction to its nature, use, preparation and safety information:
Nature:
-Appearance: Often white crystalline solid
-melting point: about 105-107 ℃
-Solubility: Soluble in some organic solvents, such as dimethyl sulfoxide and dimethyl formamide
Use:
5-(trifluoromethyl)-1H-Pyrazol-3-amine is an important organic synthesis intermediate, commonly used in the synthesis of various nitrogen-containing heterocyclic compounds. It also has applications in the field of drug research and development, and can be used as a part of drug structure or a key intermediate in drug synthesis.
Preparation Method:
In general, 5-(trifluoromethyl)-1H-Pyrazol-3-amine can be synthesized by the following steps:
1. reacting p-trifluoromethyl-1H-pyrazole with hydrazine to give 5-trifluoromethyl-1H-pyrazole.
2. react the product obtained in the previous step with an amino group to obtain 5-(trifluoromethyl)-1H-Pyrazol-3-amine.
Safety Information:
Please note the following safety precautions when using and handling this compound:
- 5-(trifluoromethyl)-1H-Pyrazol-3-amine may be irritating to the eyes, skin and respiratory tract, avoid contact.
-During operation, be sure to provide appropriate personal protective measures, such as laboratory gloves, safety glasses and protective masks.
-Seal, store, and handle the compound properly to avoid exposure to air, moisture, and ignition.
-Before use, please read and follow the relevant safety data sheet (SDS) and operating manual of the compound.