5-Amino-1-methyl-2-indolinone - Names and Identifiers
Name | 5-amino-1-methyl-1,3-dihydro-2H-indol-2-one
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Synonyms | 5-amino-1-methylindolin-2-one 5-Amino-1-methyl-2-indolinone 5-Amino-1-methyl-2-oxoindoline 5-Amino-1-methyl-1,3-dihydroindol-2-one 5-amino-1-methyl-2,3-dihydro-1H-indol-2-one 5-amino-1-methyl-1,3-dihydro-2H-indol-2-one 5-Amino-1-methyl-1,3-dihydro-2H-indol-2-one 5-Amino-1,3-dihydro-1-methyl-2H-indol-2-one 2H-Indol-2-one, 5-amino-1,3-dihydro-1-methyl-
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CAS | 20870-91-1
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InChI | InChI=1/C9H10N2O/c1-11-8-3-2-7(10)4-6(8)5-9(11)12/h2-4H,5,10H2,1H3 |
5-Amino-1-methyl-2-indolinone - Physico-chemical Properties
Molecular Formula | C9H10N2O
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Molar Mass | 162.19 |
Density | 1.263 |
Melting Point | 109 °C |
Boling Point | 472℃ |
Flash Point | 239℃ |
Vapor Presure | 4.47E-09mmHg at 25°C |
pKa | 3.51±0.20(Predicted) |
Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
Refractive Index | 1.643 |
5-Amino-1-methyl-2-indolinone - Risk and Safety
Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed.
R36/37/38 - Irritating to eyes, respiratory system and skin.
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Safety Description | S22 - Do not breathe dust.
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
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Hazard Note | Harmful |
5-Amino-1-methyl-2-indolinone - Introduction
5-amino-1-methyl-1,3-dihydro-2H-indol-2-one, also known as aminoindoline, is an important organic compound. The following is a description of its nature, use, preparation and safety information:
Nature:
1. Chemical formula: C9H10N2O
2. Appearance: colorless or light yellow crystalline solid
3. Melting Point: 112-114 degrees Celsius
4. Boiling Point: 380 degrees Celsius (decomposition)
5. Density: 1.23 g/cm
6. Solubility: low solubility in water, soluble in organic solvents such as ethanol and dichloromethane
7. Stability: stable, but explosive at high temperature, high pressure or in contact with strong oxidants
Use:
1. Indoline is an important pharmaceutical intermediate, commonly used in the production of a variety of drugs, such as anti-cancer drugs, anti-inflammatory drugs and antibacterial drugs.
2. It can also be used to synthesize dyes, rubber auxiliaries and photosensitive compounds.
Method:
The preparation of aminoindoline can be obtained by reacting indoline with methyl formate. The specific steps include reacting indoline and methyl formate under acidic conditions to produce amino-1-methyl indoline, and then obtaining 5-amino-1-methyl-1,3-dihydro-2h-indol-2-one by oxidation.
Safety Information:
1. Amino indoline need careful operation, avoid contact with skin, eyes and respiratory tract.
2. In the process of operation need to wear chemical protective gloves, glasses and work clothes and other personal protective equipment.
3. Avoid contact of ammonia indoline with fire source and oxidant to avoid explosion.
4. In storage and use, should be away from fire sources, heat sources and easy to burn materials.
5. In case of accidental contact, rinse immediately with plenty of water and seek medical help.
Last Update:2024-04-09 15:17:55