5-(chloromethyl)-3-isopropyl-1,2,4-oxadiazole - Names and Identifiers
Name | 5-(chloromethyl)-3-(propan-2-yl)-1,2,4-oxadiazole
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Synonyms | 5-(CHLOROMETHYL)-3-ISOPROPYL-1,2,4-OXADIAZOLE 5-(chloromethyl)-3-isopropyl-1,2,4-oxadiazole 5-(chloromethyl)-3-(propan-2-yl)-1,2,4-oxadiazole 1,2,4-oxadiazole, 5-(chloromethyl)-3-(1-methylethyl)-
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CAS | 54042-97-6
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InChI | InChI=1/C6H9ClN2O/c1-4(2)6-8-5(3-7)10-9-6/h4H,3H2,1-2H3 |
5-(chloromethyl)-3-isopropyl-1,2,4-oxadiazole - Physico-chemical Properties
Molecular Formula | C6H9ClN2O
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Molar Mass | 160.6 |
Density | 1.177g/cm3 |
Boling Point | 229.197°C at 760 mmHg |
Flash Point | 92.416°C |
Vapor Presure | 0.106mmHg at 25°C |
Storage Condition | 2-8°C |
Refractive Index | 1.479 |
5-(chloromethyl)-3-isopropyl-1,2,4-oxadiazole - Risk and Safety
5-(chloromethyl)-3-isopropyl-1,2,4-oxadiazole - Introduction
5-(chloromethyl)-3-(propan-2-yl)-1,2,4-oxadiazole is an organic compound with the formula C7H10ClN3O.
Nature:
-Appearance: 5-(chloromethyl)-3-(propan-2-yl)-1,2,4-oxadiazole is a colorless to pale yellow liquid.
-Solubility: Can be dissolved in some organic solvents, such as ether, acetone and ester solvents.
-Melting point and boiling point: specific values need to refer to experimental conditions and purity.
-Stability: relatively stable under normal storage conditions.
Use:
- 5-(chloromethyl)-3-(propan-2-yl)-1,2,4-oxadiazole can be used as an intermediate in organic synthesis and used in the synthesis of other organic compounds.
-In the field of pesticides and medicines, the compound has certain biological activity and can be used to design and develop new pesticides or drugs.
Preparation Method:
The general method for preparing 5-(chloromethyl)-3-(propan-2-yl)-1,2,4-oxadiazole is as follows:
1. First, by reacting 2-cyanoacetate with the electrophilic reagent required for the reaction, the corresponding 2-iminoacetate intermediate is prepared.
2. Then, under alkaline conditions, 2-iminoacetate is reacted with a chloromethylating reagent to obtain 5-chloromethyl-3-imino-1, 2,4-oxadiazole.
3. Finally, 5-(chloromethyl)-3-(propan-2-yl)-1,2,4-oxadiazole was prepared by reacting the above product with isopropanol under acidic conditions for esterification.
Safety Information:
- 5-(chloromethyl)-3-(propan-2-yl)-1,2,4-oxadiazole is an organic compound, which needs to be safe during use and storage.
-It must be protected from contact with skin, eyes or inhalation of its vapors.
-Wear appropriate personal protective equipment such as chemical protective gloves, goggles, and respiratory protection during operation.
-When disposing of waste, it should be disposed of in accordance with local regulations to avoid pollution to the environment.
Last Update:2024-04-09 21:01:54