5-(Benzyloxy)-2,4-dichloropyrimidine

5-(Benzyloxy)-2,4-dichloropyrimidine - Names and Identifiers

Name	5-(benzyloxy)-2,4-dichloropyrimidine
Synonyms	5-(benzyloxy)-2,4-dichloropyrimidine 2,4-Dichloro-5-(Benzyloxy)pyrimidine 2,4-Dichloro-5-(phenylmethoxy)pyrimidine Pyrimidine, 2,4-dichloro-5-(phenylmethoxy)-
CAS	91183-17-4
InChI	InChI=1S/C11H8Cl2N2O/c12-10-9(6-14-11(13)15-10)16-7-8-4-2-1-3-5-8/h1-6H,7H2

5-(Benzyloxy)-2,4-dichloropyrimidine - Physico-chemical Properties

Molecular Formula	C11H8Cl2N2O
Molar Mass	255.1
Density	1.382
Boling Point	381.6±27.0 °C(Predicted)
pKa	-2.70±0.29(Predicted)
Storage Condition	Inert atmosphere,Room Temperature

5-(Benzyloxy)-2,4-dichloropyrimidine - Introduction

5-(benzyloxy)-2,4-dichloropyrimidine(5-(benzyloxy)-2,4-dichloropyrimidine) is an organic compound containing a benzyl group and a chlorine atom in its structure. The following is a detailed description of the properties, uses, preparation and safety information of the compound:

Nature:
-Appearance: A white to pale yellow solid.
-Melting point: about 120-125°C.
-Molecular formula: C11H8Cl2N2O.
-Molecular weight: 257.1g/mol.

Use:
- 5-(benzyloxy)-2,4-dichloropyrimidine can be used as an intermediate in organic synthesis for the synthesis of other compounds.
-It is commonly used in the pharmaceutical field of drug research and synthesis, for example, for the synthesis of anti-tumor, anti-viral and anti-fungal drugs.

Method:
5-(benzyloxy)-2,4-dichloropyrimidine has many preparation methods, the following is one of the commonly used synthesis methods:
-First, 2,4-dichloro-5-aminopyrimidine is reacted with benzyl alcohol to generate a benzyl ether of aminopyrimidine in the presence of a base.
-Then, in an alkyl chloride (such as methyl chloride), sodium hypochlorite and sodium hydrogen hypochlorite are added to the reactant obtained in the previous step to carry out a chlorination reaction.
-Finally, the obtained product was purified by hydrolysis treatment to obtain the target compound.

Safety Information:
- 5-(benzyloxy)-2,4-dichloropyrimidine has limited toxicity information, so it is necessary to follow general laboratory safety procedures when handling or storing.
-This compound may cause irritation to the eyes, skin and respiratory tract, so wear appropriate protective equipment such as glasses, gloves and protective face masks when handling.
-It should be kept in a dry, well-ventilated place and away from flammable materials and oxidants.

Last Update：2024-04-09 21:01:54

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