Molecular Formula | C12H15BN2O2 |
Molar Mass | 230.07 |
Density | 1.10 |
Melting Point | 105-106℃ |
Boling Point | 370.7±27.0 °C(Predicted) |
Flash Point | 178°C |
Water Solubility | Slightly soluble in water. |
Vapor Presure | 1.09E-05mmHg at 25°C |
Appearance | powder to crystal |
Color | White to Light yellow to Light orange |
pKa | -0.33±0.12(Predicted) |
Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
Refractive Index | 1.506 |
MDL | MFCD06657825 |
Hazard Symbols | Xi - Irritant |
Risk Codes | R37/38 - Irritating to respiratory system and skin. R41 - Risk of serious damage to eyes |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S39 - Wear eye / face protection. |
Use | 2-cyanopyridine-5-boronic acid pinacyl Ester is an organic intermediate, can be used for Suzuki and other metal coupling reaction. It has been reported in the literature that it can be used to prepare vascular adhesion protein (VAP)-1 inhibitors. |
preparation | to 5-bromo-pyridine-2-carbonitrile (2G, 10.92mmol) in dioxane (60ml) to the solution in, add dual-frequency diborane (3.33g,13.11mmol) and potassium acetate (1.6g,16.39mmol), Degas the reaction mixture, add tricyclohexylphosphine (0.4g,1.42mmol) and Pd2(dba)3(0.5g,0.546mmol), heated to 90 °c overnight. Dilute with water and ethyl acetate. the organic layer was separated, dried over sodium sulfate, and the solvent was evaporated in vacuo to give a crude product, which was purified by column chromatography (eluting with 6-8% ethyl acetate in hexane), 2-cyanopyridine-5-boronic acid radical ester (1.0g) was obtained. |