4氨基-2-甲巯基嘧啶-5-甲酯

4氨基-2-甲巯基嘧啶-5-甲酯 - Names and Identifiers

Name	4-amino-2-methylsulfanyl-pyrimidine-5-carbaldehyde
Synonyms	Benzene,1-ethenyl-8-nitro- 2-METHYLTHIO 4-AMINO 5-FORMYL PYRIMIDINE 4-amino-2-methylthiopyrimidine-5-carbaldehyde 4-AMINO-2-METHYLTHIO-PYRIMIDINE-5-CARBALDEHYDE 4-Amino-2-methylthio-pyrimidine-5-carbaldehyde 4-amino-2-(methylthio)pyrimidine-5-carbaldehyde 4-Amino-2-(methylthio)pyrimidine-5-carbaldehyde 4-Amino-2-(methylthio)pyrimidine-5-carboxaldehyde 4-AMino-2-(Methylthio)-5-pyriMidinecarboxaldehyde 4-amino-2-methylsulfanyl-pyrimidine-5-carbaldehyde 5-PYRIMIDINECARBOXALDEHYDE, 4-AMINO-2-(METHYLTHIO)- 5-Pyrimidinecarboxaldehyde, 4-amino-2-(methylthio)- 4-Amino-2-(methylsulfanyl)pyrimidine-5-carbaldehyde 4-aMino-2-Methanesulfanyl-pyriMidine-5-carboxaldehyde
CAS	770-31-0
EINECS	220-644-8

4氨基-2-甲巯基嘧啶-5-甲酯 - Physico-chemical Properties

Molecular Formula	C6H7N3OS
Molar Mass	169.2
Density	1.37
Melting Point	183-184 °C
Boling Point	379.7±27.0 °C(Predicted)
Flash Point	183.4 °C
pKa	2.50±0.10(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2–8 °C

4氨基-2-甲巯基嘧啶-5-甲酯 - Reference Information

Application

4-amino-2-thiopyrimidine-5-formaldehyde is an intermediate of many medicines and pesticides, it is also a versatile intermediate in organic synthesis. 4-amino -2-thiopyrimidine -5-formaldehyde was used in the synthesis of PamapimodR1487 and homologous p38 mitogen-activated protein kinase inhibitors, this intermediate is also frequently used in many drug molecules and in organic synthesis.

synthesis method

The preparation steps of 4-amino-2-thiopyrimidine-5-formaldehyde are as follows: 0. 15 to 0. 25mol of cyanoacetaldehyde diethanol acetal or cyanoacetaldehyde dimethanol acetal was dissolved in tetrahydrofuran and added at a temperature of 10-20°C. 20 to 0. 30mol of sodium methoxide was stirred at 10-20°C for 1-2 hours; The reaction was kept warm and slowly added dropwise. 20 to 0.50ml of a 30mol solution of methyl formate in Tetrahydrofuran, and the mixture is stirred at 10-20°C for 5-7 hours after the completion of the dropping; After the above reaction, the mixture is cooled to 10-20°C, then slowly add 0. 20 to 0. 25mol sodium methoxide, raise the temperature to 60-70°C, slowly add Dropwise 0. 15 to 0. 25mol 2-methyl -2-mercaptosulfuric acid urea, after dropping at 60~70°C for 4~6 hours; After the reaction, remove the solvent under reduced pressure, then 80~120ml of a mixture of ethanol and water was added to the reaction system, stirred at 10~20°C for 40~80 minutes and then suction filtered to collect a light yellow solid. The mixture of alcohol and water is washed once and then washed once or twice with water, and dried to give pale yellow crystals, namely 4-amino-2-thiopyrimidine-5-carbaldehyde.

Last Update：2024-04-09 02:00:11