Application | Anti-lodging amine (N-[4-chloro-2-(hydroxybenzyl) phenyl] pyridine-4-formamide, inabenfide) is a plant growth retarder that can inhibit the synthesis of gibberellin in rice plants, it has a strong selective lodging resistance to rice. After the application of this product, the number of grains per panicle of rice decreases, but the grain maturity rate increases, which increases the actual yield. Therefore, anti-pour amines are widely used in rice production. |
preparation | anti-pour amine is prepared as follows: isonicotinic acid is used as the starting material, chlorinated by phthalide, and 2-amino -5-chlorobenzophenone is reacted at a controlled temperature. After obtaining the intermediate ketone, the reduction reaction is carried out to obtain the final product anti-inverted amine. Specific operation steps: 13.5g (0.1 mo) isonicotinic acid is placed in a 260 ml three-mouth bottle, 80g organic solvent is added, and 13.1g (0.1 mo) dichlorosulfoxide is added dropwise at a certain temperature. After dropping, continue to stir for 2-3 hours, and then drop 23.2 grams (0.1 mo) 2-nitro-5-chloro-benzophenone * dissolved in 40 grams of organic solvent solution. After stirring reaction, the system changes from suspended turbidity to clear liquid, and gradually precipitate solid, continue to stir for 2-4 hours, cool, dilute with water, filter and wash with water to obtain yellow needle crystal with melting point of 154 ℃. Dissolve the above crystals in 120 ml of methanol, add a certain amount of reducing agent in batches at a certain temperature, and stir for 2-4 hours. Heat and stir for reaction hours. Cooling, filtering, washing with methanol and water in turn, drying, 30.8 grams of light yellow solid, 95% yield, melting point 208~209 ℃. After recrystallization, the melting point of the product is 220~222 ℃. |
category | pesticide |
toxicity classification | low toxicity |
acute toxicity | oral-rat LD50: > 15000 mg/kg; Oral-mouse LD50: > 15000 mg/kg |
flammability hazard characteristics | flammability; decomposition of toxic nitrogen oxides and chloride smoke at the fire site |
storage and transportation characteristics | warehouse low temperature, ventilation, drying |
extinguishing agent | water, carbon dioxide, dry powder, sand |