4H-1,3-Benzoxazin-4-one, 8-(4-dibenzothienyl)-2-(4-morpholinyl)-
LTURM34
CAS: 1879887-96-3
Molecular Formula: C24H18N2O3S
4H-1,3-Benzoxazin-4-one, 8-(4-dibenzothienyl)-2-(4-morpholinyl)- - Names and Identifiers
| Name | LTURM34 |
| Synonyms | LTURM34 CS-2622 LTURM 34 LTURM-34 8-(4-Dibenzothienyll)-2-(4-morpholinyl)-4H-1,3-benzoxazin-4-one 4H-1,3-Benzoxazin-4-one, 8-(4-dibenzothienyl)-2-(4-morpholinyl)- |
| CAS | 1879887-96-3 |
4H-1,3-Benzoxazin-4-one, 8-(4-dibenzothienyl)-2-(4-morpholinyl)- - Physico-chemical Properties
| Molecular Formula | C24H18N2O3S |
| Molar Mass | 414.48 |
| Storage Condition | 2-8°C |
| In vitro study | LTURM34 shows potent inhibition of DNA-PK with excellent selectivity over the Class I PI3K isoforms. The IC 50 s are 5.8 and 8.5 μM for PI3K β and δ, respectively. LTURM34 is more consistently active against the selected cell lines (11 of 16), but at best shows 54% inhibition against the HOP-92 non-small cell lung cancer line. |
4H-1,3-Benzoxazin-4-one, 8-(4-dibenzothienyl)-2-(4-morpholinyl)- - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.413 ml | 12.063 ml | 24.127 ml |
| 5 mM | 0.483 ml | 2.413 ml | 4.825 ml |
| 10 mM | 0.241 ml | 1.206 ml | 2.413 ml |
| 5 mM | 0.048 ml | 0.241 ml | 0.483 ml |
Last Update：2024-01-02 23:10:35
4H-1,3-Benzoxazin-4-one, 8-(4-dibenzothienyl)-2-(4-morpholinyl)- - Reference Information
| biological activity | LTURM34 is a specific DNA-PK inhibitor (IC50=34 nM). Compared with PI3K, the selectivity of LTURM34 for DNA-PK is 170 times higher. LTURM34 showed potent antiproliferative activity in a variety of tumor cell lines. |
| target | DNA-PK 34 nM (IC 50 ) PI3Kβ 5.8 μM (IC 50 ) PI4Kδ 8.5 μM (IC 50 ) |
| in vitro study | LTURM34 shows potent inhibition of DNA-PK with excellent selectivity over the Class I PI3K isoforms. The IC 50 s are 5.8 and 8.5 μM for PI3K β and δ, respectively. LTURM34 is more consistently active against the selected cell lines (11 of 16), but at best shows 54% inhibition against the HOP-92 non-small cell lung cancer line. |
Last Update：2024-04-09 21:21:28
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View History
4H-1,3-Benzoxazin-4-one, 8-(4-dibenzothienyl)-2-(4-morpholinyl)-
1-boc-piperidine-4-carboxylic acid
3-氰丙基甲基二氯硅烷
3-氨基-2-羟基苯
(3aR,4S,5R,6aS)-4-(tert-Butyldimethylsilyloxy)methyl-5-tetrahydropyranyloxy-hexahydro-2H-cyclopenta[b]furan-2-one
1-METHYL-2-(TRIMETHYLSILYL) IMIDAZOLE
(2,5-dichlorophenyl)(2,3,5,6-tetrachlorophenyl)methanamine
Mepiquat D3
吡啶,2-[(4-硝基苯基)甲基]-
1-boc-piperidine-4-carboxylic acid
3-氰丙基甲基二氯硅烷
3-氨基-2-羟基苯
(3aR,4S,5R,6aS)-4-(tert-Butyldimethylsilyloxy)methyl-5-tetrahydropyranyloxy-hexahydro-2H-cyclopenta[b]furan-2-one
1-METHYL-2-(TRIMETHYLSILYL) IMIDAZOLE
(2,5-dichlorophenyl)(2,3,5,6-tetrachlorophenyl)methanamine
Mepiquat D3
吡啶,2-[(4-硝基苯基)甲基]-