LTURM34 MedChemExpress (MCE)

Product Name	LTURM34
Synonyms	LTURM34;CS-2622;LTURM 34; LTURM-34;8-(4-Dibenzothienyll)-2-(4-morpholinyl)-4H-1,3-benzoxazin-4-one;4H-1,3-Benzoxazin-4-one, 8-(4-dibenzothienyl)-2-(4-morpholinyl)-
CAS	1879887-96-3
EINECS
Chemical Formula	C24H18N2O3S
Molecular Weight	414.48
inchi
Package	10 mM * 1 mL;1 mg;5 mg;10 mg;25 mg;50 mg
Price	Email to quote
Descriptions	LTURM34 LTURM34 MedChemExpress (MCE) HY-101667 1879887-96-3 99.35% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US Descriptions LTURM34 LTURM34 MedChemExpress (MCE) HY-101667 1879887-96-3 99.35% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. LTURM34 is a specific DNA-PK inhibitor (IC50=34 nM). LTURM34 exhibits 170-fold selectivity for DNA-PK over PI3K. LTURM34 shows potent antiproliferative activity in a wide range of tumor cell lines. LTURM34 shows potent inhibition of DNA-PK with excellent selectivity over the Class I PI3K isoforms. The IC50s are 5.8 and 8.5 μM for PI3K β and δ, respectively. LTURM34 is more consistently active against the selected cell lines (11 of 16), but at best shows 54% inhibition against the HOP-92 non-small cell lung cancer line[1]. LTURM34 is dissolved at 10 mM in DMSO and stored at -20°C until use. PI3K enzyme activity is determined in 50 μL of 20 mM HEPES pH 7.5, 5 mM MgCl2 with 180 μM PI and 10 μM ATP. After a 60 min incubation at room temperature the reaction is stopped by the addition of 50 μl of Kinase-Glo followed by a further 15 min incubation. Luminescence is then read using a luostar plate reader. LTURM34 is diluted in 20% (v/v) DMSO at the ndicated concentrations in order to generate a concentration versus inhibition of enzyme activity curve which is then analysed using GraphPad Prism version 5.00 for Windows, in order to calculate the IC50[1]. DNA-PK 34 nM (IC50) PI3Kβ 5.8 μM (IC50) PI4Kδ 8.5 μM (IC50) \| \| \| \| \| \| \| \| \| \| [1]. Morrison R, et al. Synthesis, structure elucidation, DNA-PK and PI3K and anti-cancer activity of 8- and 6-aryl-substituted-1-3-benzoxazines. Eur J Med Chem. 2016 Mar 3 110:326-39. [Content Brief]
Supplier Website	https://www.medchemexpress.com/LTURM34.html
Last Update	2025-05-21 16:50:25

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