Molecular Formula | C25H24O5 |
Molar Mass | 404.46 |
Density | 1.258±0.06 g/cm3(Predicted) |
Melting Point | 189° (uncorr), 193° (corr) |
Boling Point | 632.3±55.0 °C(Predicted) |
Appearance | Lemon yellow |
pKa | 7.00±0.40(Predicted) |
Storage Condition | -20°C |
Use | Antioxidant |
In vitro study | Osajin significantly decreases the viability of human NPC cells (TW076, CG1 and TW04 cells) in a dose-dependent manner. Osajin induces apoptosis in human NPC cells through multiple apoptotic pathways, including the extrinsic death receptor pathway, and intrinsic pathways relying on mitochondria and endoplasmic reticulum stress. Osajin exhibits growth inhibitory activity on six human cancer cell lines, including kidney, lung, prostate, breast, melanoma and colon cancer cells. |
In vivo study | Osajin and pomiferin attenuates the myocardial dysfunction provoked by ischemia reperfusion. This is confirmed by an increase in both antioxidant enzyme values and total antioxidant activity. The cardioprotection provided by osajin and pomiferin treatment results from the suppression of oxidative stress and this correlates with improved ventricular function. |
Hazard Symbols | N - Dangerous for the environment |
Risk Codes | 50 - Very Toxic to aquatic organisms |
Safety Description | 61 - Avoid release to the environment. Refer to special instructions / safety data sheets. |
UN IDs | UN 3077 9 / PGIII |
WGK Germany | 3 |
biological activity | osajing is the main bioactive isoflavone present in Maclura pomifera fruit, which has antitumor, antioxidant and anti-inflammatory activities. |
Target | apotosis |