458532-88-2 - Names and Identifiers
Name | 3-Fluoropyridine-4-boronic acid pinacol ester
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Synonyms | 3-Fluoro-4-pyridineboronic acid pinacol ester 3-Fluoropyridine-4-boronic acid pinacol ester 3-Fluorpyridine-4-boronic acid pinacolic ester 3-fluoro-4-(tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridine 3-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 3-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxoborolan-2-yl)pyridine 4-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 3-Fluoro-4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)Pyridine 3-FLUORO-4-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDINE Pyridine, 3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)- pyridine, 3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
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CAS | 458532-88-2
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InChI | InChI=1/C11H15BFNO2/c1-10(2)11(3,4)16-12(15-10)8-5-6-14-7-9(8)13/h5-7H,1-4H3 |
458532-88-2 - Physico-chemical Properties
Molecular Formula | C11H15BFNO2
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Molar Mass | 223.05 |
Density | 1.09±0.1 g/cm3(Predicted) |
Melting Point | 125-127°C |
Boling Point | 292.4±25.0 °C(Predicted) |
Flash Point | 130.7°C |
Vapor Presure | 0.00321mmHg at 25°C |
pKa | 1.97±0.20(Predicted) |
Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
Refractive Index | 1.477 |
MDL | MFCD06798251 |
458532-88-2 - Risk and Safety
Hazard Symbols | Xi - Irritant
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Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin.
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Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36 - Wear suitable protective clothing.
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WGK Germany | 3 |
Hazard Class | IRRITANT |
458532-88-2 - Introduction
3-Fluoropyridine-4-boronic acid pinacol ester is an organic compound containing a fluorine atom, a pyridine ring, and a boronic acid group in its chemical structure. The following is its nature, use, method and safety information:
Nature:
-Appearance: Colorless or light yellow solid
-Molecular formula: C12H14BFNO2
-Molecular weight: 251.06g/mol
-melting point: 48-51 ℃
-boiling point: 215-217 ℃
Use:
3-Fluoropyridine-4-boronic acid pinacol ester is an intermediate used in organic synthetic chemistry. It can be used as protease inhibitors, drug intermediates and ligand molecules and other important compounds. In addition, the substance can also be used for cross-coupling reactions in organic synthesis reactions, such as phenyl modification reactions, olefin synthesis, etc.
Preparation Method:
3-fluoropyridine-4-boronic acid pinacol ester is prepared by various methods. the common one is to react 3-fluoropyridine with boronic ester (such as phenolether) under acidic conditions.
Safety Information:
3-Fluoropyridine-4-boronic acid pinacol ester has good safety under general conditions of use. However, as an organic synthetic chemical, it still needs to be handled with caution. When in use, should wear appropriate personal protective equipment, avoid contact with skin, eyes and intake. For accidental contact, rinse immediately with plenty of water and seek professional medical help. In addition, the material should be stored and transported away from high temperature, direct sunlight and fire sources, and stored in a dry, well-ventilated place. Detailed safety operation recommendations can refer to the relevant safety data sheets and chemical safety operation manuals.
Last Update:2024-04-09 20:52:54