438565-35-6 - Names and Identifiers
438565-35-6 - Physico-chemical Properties
438565-35-6 - Introduction
[3-(3-Nitro-phenyl)-isoxazol-5-yl]-methanol is an organic compound with the chemical formula C10H8N2O4. The following is an introduction to its nature, use, preparation and safety information:
Nature:
-Appearance: Colorless to light yellow solid
-Melting point: approximately 150-155°C
-Solubility: Soluble in organic solvents such as ethanol, dimethylformamide (DMF), insoluble in water
-Main functional groups: nitro (NO2), phenyl (C6H5), isoxazole (C3H3NO)
Use:
- [3-(3-Nitro-phenyl)-isoxazol-5-yl]-methanol is a commonly used chemical reagent and intermediate, which can be widely used in the fields of drug synthesis, pesticide synthesis and organic synthesis.
-It can be used as a starting material for the preparation of biologically active compounds, such as antitumor drugs, antiviral drugs, etc.
Preparation Method:
The preparation of [3-(3-Nitro-phenyl)-isoxazol-5-yl]-methanol can be carried out by the following steps:
1. Benzene-2-one (C6H5COCH3) is reacted with sodium hydroxide (NaOH) in an appropriate solvent to give benzene-2-ol (C6H5CHOH).
2. Under alkaline conditions, benzene -2-alcohol reacts with sodium nitrite (NaNO2) to generate 3-nitrobenzyl alcohol (C6H4NO2CH2OH).
3. The obtained product is reacted with isoxazole to obtain [3-(3-Nitro-phenyl)-isoxazol-5-yl]-methanol under acid catalysis.
Safety Information:
- [3-(3-Nitro-phenyl)-isoxazol-5-yl]-methanol is an organic compound with potential toxicity and irritation.
-Wear appropriate protective equipment such as gloves, goggles and lab coats during operation.
-Avoid inhalation, avoid contact with skin and eyes.
-Pay attention to fire prevention and electrostatic discharge during storage and handling.
-Please read the relevant safety technical instructions carefully before use, and follow the correct operating methods and laboratory safety procedures.
Last Update:2024-04-09 02:00:46