405168-58-3
CHIR-124
CAS: 405168-58-3
Molecular Formula: C23H22ClN5O
405168-58-3 - Names and Identifiers
405168-58-3 - Physico-chemical Properties
| Molecular Formula | C23H22ClN5O |
| Molar Mass | 419.91 |
| Density | 1.46 |
| Storage Condition | -20℃ |
| In vitro study | CHIR-124 is a small quinolone molecule that is structurally unrelated to other known Chk1 inhibitors. CHIR-124 and topoisomerase toxicants (eg, Camptothecin or SN-38) work synergistically to inhibit the growth of a variety of cancer cell lines, including breast (MDA-MB-231 and MDA-MB-435) and colon (SW-620 and Colo205), these tumors all have p53 mutations. CHIR-124 acts on MDA-MD-435 breast cancer cells, abrogating SN-38-induced S-and G2-M-phase checkpoints, and enhancing apoptosis. p53 deletion enhances CHIR-124 resulting in G2-M checkpoint abrogation and induction of apoptosis. |
405168-58-3 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.381 ml | 11.907 ml | 23.815 ml |
| 5 mM | 0.476 ml | 2.381 ml | 4.763 ml |
| 10 mM | 0.238 ml | 1.191 ml | 2.381 ml |
| 5 mM | 0.048 ml | 0.238 ml | 0.476 ml |
Last Update：2024-01-02 23:10:35
405168-58-3 - Reference Information
| biological activity | CHIR-124 is a novel potent Chk1 inhibitor with an IC50 of 0.3 nM in a cell-free assay. The selectivity was 2000-fold higher than that for Chk2 and 500 to 5000-fold higher than that for CDK2/4 and Cdc2. |
| Target | Value |
| Chk1 (Cell-free assay) | 0.3 nM |
| FLT3 (Cell-free assay) | 5.8 nM |
| PDGFR (Cell-free assay) | 6.6 nM |
| GSK-3 (Cell-free assay) | 23.3 nM |
Last Update：2024-04-09 21:54:55
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CAS: 405168-58-3
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View History
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