4-羟基-3-三氟甲基苯腈

4-羟基-3-三氟甲基苯腈 - Names and Identifiers

Name	4-Hydroxy-3-(trifluoromethyl)benzonitrile
Synonyms	NCR DQ CXFFF [WLN] 5-Cyano-2-hydroxybenzotrifluoride 4-Hydroxy-3-(trifluoromethyl)benzonitrile 4-HYDROXY-3-(TRIFLUOROMETHYL)BENZONITRILE Benzonitrile, 4-hydroxy-3-(trifluoromethyl)- alpha,alpha,alpha-Trifluoro-4-hydroxy-m-tolunitrile 4-Cyano-2-(trifluoromethyl)phenol, 5-Cyano-2-hydroxybenzotrifluoride
CAS	124811-71-8
InChI	InChI=1/C8H4F3NO/c9-8(10,11)6-3-5(4-12)1-2-7(6)13/h1-3,13H

4-羟基-3-三氟甲基苯腈 - Physico-chemical Properties

Molecular Formula	C8H4F3NO
Molar Mass	187.12
Density	1.44±0.1 g/cm3(Predicted)
Melting Point	171-175℃
Boling Point	256.0±40.0 °C(Predicted)
Flash Point	108.6°C
Water Solubility	Insoluble in water.
Solubility	Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
Vapor Presure	0.00983mmHg at 25°C
Appearance	White to Brown Powder
Color	Pale Brown
pKa	5.85±0.43(Predicted)
Storage Condition	Inert atmosphere,Room Temperature
Refractive Index	1.495
MDL	MFCD06797882

4-羟基-3-三氟甲基苯腈 - Risk and Safety

Hazard Symbols	Xi - Irritant
Hazard Note	Irritant

4-羟基-3-三氟甲基苯腈 - Introduction

4-Hydroxy-3-trifluoromethylbenzonitrile (-) is an organic compound with the chemical formula C8H4F3NO. The following is a description of its nature, use, preparation and safety information:

Nature:
-Appearance: 4-hydroxy-3-trifluoromethylbenzonitrile is a colorless to pale yellow solid.
-Solubility: It does not dissolve in water, but has better solubility in organic solvents.
-Melting point: Its melting point is about 107-109 degrees Celsius.

Use:
-4-hydroxy-3-trifluoromethylbenzonitrile can be used as an important intermediate in organic synthesis and used in the synthesis of other organic compounds.
-It can also be applied to certain research and synthesis processes in the field of medicine.

Method:
The preparation method of 4-hydroxy-3-trifluoromethylbenzonitrile can be achieved by the following steps:
1. reacting benzonitrile with trifluoromethyl alcohol to give 3-trifluoromethylbenzonitrile.
2. 3-trifluoromethylbenzonitrile is reacted with sodium hydroxide (NaOH) to obtain 4-hydroxy-3-trifluoromethylbenzonitrile.

Safety Information:
Regarding the safety of 4-hydroxy-3-trifluoromethylbenzonitrile, the following are some basic safety information:
-This compound may be irritating to the skin, eyes and respiratory tract.
-When using or handling, follow appropriate safety practices, including wearing personal protective equipment such as gloves, safety glasses and protective face shields.
-Avoid inhaling its vapors or dust, avoid contact with skin and eyes.
-In case of inadvertent contact, immediately flush the infected area with plenty of water and seek medical help.

it should be noted that the above information is only a general description of 4-hydroxy-3-trifluoromethylbenzonitrile, and the specific properties, uses and safety information may need to be further understood and confirmed according to the specific situation. Laboratory safety and professional guidance should be strictly followed when using chemicals.

Last Update：2024-04-09 21:54:55