4-甲磺酰基苯甲酸甲酯
methyl 4-(methylsulfonyl)benzoate
CAS: 22821-70-1
Molecular Formula: C9H10O4S
4-甲磺酰基苯甲酸甲酯 - Names and Identifiers
4-甲磺酰基苯甲酸甲酯 - Physico-chemical Properties
| Molecular Formula | C9H10O4S |
| Molar Mass | 214.24 |
| Density | 1.266±0.06 g/cm3(Predicted) |
| Melting Point | 118-120 °C |
| Boling Point | 377.8±34.0 °C(Predicted) |
| Flash Point | 182.3°C |
| Vapor Presure | 6.58E-06mmHg at 25°C |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.518 |
4-甲磺酰基苯甲酸甲酯 - Reference Information
| application | methyl 4-methylsulfonyl benzoate is an aryl sulfone compound, which can be used as an intermediate in pharmaceutical synthesis and an intermediate in organic synthesis, and is mainly used in laboratory research and development process and chemical pharmaceutical synthesis process. |
| preparation | in a reaction tube, add 262mg of ethyl p-iodide (MW = 262.04,1.0mmol), then add 153mg of sodium methyl sulfonate (MW = 102.09,1.2mmol, content 80%),28mgL-proline sodium salt (MW = 137.05,0.2mmol),19mgCuI(MW = 190.45,0.1mmol),2mlDMSO is used as a solvent, under the protection of nitrogen, react in an oil bath at 80 ℃ for 36 hours, cool, add 4 ml of water, extract with 10 ml of ethyl acetate each time, repeat three times, wash the extract with saturated salt water, dry with anhydrous sodium sulfate, filter, distill the filtrate under reduced pressure, and separate it through a silica gel column (eluent petroleum ether: ethyl acetate = 3: 1) to obtain 158mg of the product 4-methylsulfonyl benzoate with a yield of 77%. |
Last Update：2024-04-09 20:52:54
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View History
4-甲磺酰基苯甲酸甲酯
L-Lysine, compd. with 4-[2-[(1R,2R)-2-(2,4-difluorophenyl)-1-methyl-2-[(phosphonooxy)methoxy]-3-(1H-1,2,4-triazol-1-yl)propyl]-4-thiazolyl]benzonitrile (1:1)
5-甲基氧杂环戊烷-3-胺盐酸盐
2-羰基-3-三甲基硅-1,3-唑烷酮
富马酸贝达喹啉杂质7
2-(2-(Prop-2-yn-1-yloxy)ethoxy)acetic acid
5-[Acetyloxy)methyl]-tricyclo[2.2.1.02,6]heptanone
(R)-叔丁基3-氨基吡咯烷-1-羧酸酯盐酸盐
3-叔丁基-4-羟基苯甲醚
富马酸替诺福韦酯杂质4
L-Lysine, compd. with 4-[2-[(1R,2R)-2-(2,4-difluorophenyl)-1-methyl-2-[(phosphonooxy)methoxy]-3-(1H-1,2,4-triazol-1-yl)propyl]-4-thiazolyl]benzonitrile (1:1)
5-甲基氧杂环戊烷-3-胺盐酸盐
2-羰基-3-三甲基硅-1,3-唑烷酮
富马酸贝达喹啉杂质7
2-(2-(Prop-2-yn-1-yloxy)ethoxy)acetic acid
5-[Acetyloxy)methyl]-tricyclo[2.2.1.02,6]heptanone
(R)-叔丁基3-氨基吡咯烷-1-羧酸酯盐酸盐
3-叔丁基-4-羟基苯甲醚
富马酸替诺福韦酯杂质4