tert-Butyl is an organic compound with the chemical formula C14H22N3O3.
Nature:
-Appearance: Colorless liquid or white crystalline solid.
-Melting point: about 70°C.
-Boiling point: about 282°C.
-Solubility: Soluble in ethanol, ether and organic solvents.
Use:
tert-Butyl has a variety of uses in drug development and organic synthesis, such:
-Used as a catalyst in the reaction of organic synthesis.
-Used as an intermediate for the preparation of biologically active compounds.
Preparation Method:
tert-Butyl can be synthesized by the following steps:
1. reacting 4-morpholino-piperidine-1-iodomethane with tert-butanol to generate 4-morpholino-piperidine-1-hydroxymethane;
2. reacting 4-morpholino-piperidine-1-hydroxymethane with sodium cyanide in DMF (dimethylformamide) to generate 4-morpholino-piperidine-1-carbonitrile;
3. React 4 morpholino piperidine-1-carbonitrile with tert-butyl chloroformate under conditions to generate tert-Butyl-alkaline.
Safety Information:
tert-Butyl is relatively safe under correct use and storage, but the following safety precautions must be observed:
-Avoid contact with skin, eyes and inhalation.
-Wear appropriate protective gloves and glasses when using.
-Use in a well-ventilated place to avoid the accumulation of harmful gases.
-Store away from open flames and high temperatures.
-If exposed or taken by mistake, seek medical attention and bring information about the compound.