4-氟-3-甲醛苯甲酸甲酯
4-Fluoro-3-formylbenzoic acid methyl ester
CAS: 1093865-65-6
Molecular Formula: C9H7FO3
4-氟-3-甲醛苯甲酸甲酯 - Names and Identifiers
| Name | 4-Fluoro-3-formylbenzoic acid methyl ester |
| Synonyms | Methyl 4-fluoro-3-formylbenzoate Methyl 4-fluoro-3-forMylbenzoate 4-Fluoro-3-formylbenzoic acid methyl ester Benzoic acid, 4-fluoro-3-formyl-, methyl ester |
| CAS | 1093865-65-6 |
| InChI | InChI=1S/C9H7FO3/c1-13-9(12)6-2-3-8(10)7(4-6)5-11/h2-5H,1H3 |
4-氟-3-甲醛苯甲酸甲酯 - Physico-chemical Properties
| Molecular Formula | C9H7FO3 |
| Molar Mass | 182.15 |
| Density | 1.271 |
| Boling Point | 275℃ |
| Flash Point | 117℃ |
| Storage Condition | Inert atmosphere,Room Temperature |
4-氟-3-甲醛苯甲酸甲酯 - Introduction
Methyl 4-fluoro-3-carbaldehyde benzoate, chemical formula C8H7FO3, is also known as FMOC methyl ester. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: White crystalline solid.
-Melting point: about 54-56 degrees Celsius.
-Stability: Stable at room temperature, but can be decomposed at high temperature.
-Solubility: Soluble in organic solvents such as dichloromethane and dimethyl sulfoxide, slightly soluble in ethanol and benzene.
Use:
-as a protecting group in organic synthesis: 4-fluoro-3-carbaldehyde benzoic acid methyl ester can be used as a cis-protecting group in the synthesis. It can protect the amino, hydroxyl and other functional groups to prevent them from unnecessary reactions.
-Chemical synthesis: It can be used to synthesize chemicals containing aromatic compounds, such as pharmaceutical intermediates, heterocyclic compounds, etc.
Preparation Method:
The preparation of 4-fluoro-3-formaldehyde benzoic acid methyl ester is mainly based on organic synthesis methods. One commonly used method of preparation is the reaction of methyl ketone with p-fluorobenzoic anhydride to obtain methyl 4-fluoro-3-carbaldehyde benzoate.
Safety Information:
-Irritating and corrosive to the skin, avoid contact with the skin.
-May cause serious irritation and damage to eyes, should avoid contact with eyes.
-Women who may be infected with the fetus should take precautions to avoid exposure to this compound.
-Pay attention to good ventilation during use to prevent its vapor from accumulating in the air and causing poisoning.
-Waste should be disposed of in a safe manner, following local rules and regulations.
Nature:
-Appearance: White crystalline solid.
-Melting point: about 54-56 degrees Celsius.
-Stability: Stable at room temperature, but can be decomposed at high temperature.
-Solubility: Soluble in organic solvents such as dichloromethane and dimethyl sulfoxide, slightly soluble in ethanol and benzene.
Use:
-as a protecting group in organic synthesis: 4-fluoro-3-carbaldehyde benzoic acid methyl ester can be used as a cis-protecting group in the synthesis. It can protect the amino, hydroxyl and other functional groups to prevent them from unnecessary reactions.
-Chemical synthesis: It can be used to synthesize chemicals containing aromatic compounds, such as pharmaceutical intermediates, heterocyclic compounds, etc.
Preparation Method:
The preparation of 4-fluoro-3-formaldehyde benzoic acid methyl ester is mainly based on organic synthesis methods. One commonly used method of preparation is the reaction of methyl ketone with p-fluorobenzoic anhydride to obtain methyl 4-fluoro-3-carbaldehyde benzoate.
Safety Information:
-Irritating and corrosive to the skin, avoid contact with the skin.
-May cause serious irritation and damage to eyes, should avoid contact with eyes.
-Women who may be infected with the fetus should take precautions to avoid exposure to this compound.
-Pay attention to good ventilation during use to prevent its vapor from accumulating in the air and causing poisoning.
-Waste should be disposed of in a safe manner, following local rules and regulations.
Last Update：2024-04-09 02:00:41
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View History
4-氟-3-甲醛苯甲酸甲酯
N-TERT-BUTYLOXYCARBONYL-11-AMINO-UNDECANOIC ACID
二(叔丁基二环己基磷)氯化钯
2'-氟-3'-(三氟甲基)苯乙酮
4-溴-N-十二基-1-羟基-2-萘甲酰胺
苦绳苷元A
磷酸-2-乙基己基酯
乙醇,2-[(5-硝基-2-吡啶基)氨基]-
2,6-双(吡唑-1-基)吡啶-4-羧酸
1-[[4-[(4-氟-2-甲基-1H-吲哚-5-基)氧基]-5-甲基吡咯并[2,1-F][1,2,4]三嗪-6-基]氧基]-2-丙醇 L-丙氨酸酯
N-TERT-BUTYLOXYCARBONYL-11-AMINO-UNDECANOIC ACID
二(叔丁基二环己基磷)氯化钯
2'-氟-3'-(三氟甲基)苯乙酮
4-溴-N-十二基-1-羟基-2-萘甲酰胺
苦绳苷元A
磷酸-2-乙基己基酯
乙醇,2-[(5-硝基-2-吡啶基)氨基]-
2,6-双(吡唑-1-基)吡啶-4-羧酸
1-[[4-[(4-氟-2-甲基-1H-吲哚-5-基)氧基]-5-甲基吡咯并[2,1-F][1,2,4]三嗪-6-基]氧基]-2-丙醇 L-丙氨酸酯