4-amylcinnamoylanthranilicacid

Name	N-(p-Amylcinnamoyl)anthranilic acid
Synonyms	ACA 4-amylcinnamoylanthranilicacid N-(p-Amylcinnamoyl)anthranilic acid N-(P-AMYLCINNAMOYL)ANTHRANILIC ACID N-(p-Amylcinnamoyl) anthranilic Acid (ACA) 2-(3-(4-Pentylphenyl)acrylamido)benzoic acid 2-[[(E)-3-(4-PENTYLPHENYL)PROP-2-ENOYL]AMINO]BENZOIC ACID Benzoic acid, 2-[[1-oxo-3-(4-pentylphenyl)-2-propen-1-yl]amino]-
CAS	110683-10-8

Molecular Formula	C21H23NO3
Molar Mass	337.41
Density	1.178±0.06 g/cm3(Predicted)
Melting Point	172-174℃
Boling Point	563.1±50.0 °C(Predicted)
Solubility	DMSO: ≥20 mg/mL
Appearance	White to white-like powder
Color	White to Off-White
pKa	3.49±0.36(Predicted)
Storage Condition	Sealed in dry,Room Temperature
In vitro study	N-(p-amylcinnamoyl) Anthranilic Acid (ACA; 20 μM) completely blocks ADPR-induced whole-cell currents and H 2 O 2 -induced Ca 2+ signals (IC 50 =1.7 μM) in HEK293cells transfected with human TRPM2. N-(p-amylcinnamoyl) Anthranilic Acid (ACA; 20 μM) also blocks currents through human TRPM8 and TRPC6 expressed in HEK293 cells. N-(p-amylcinnamoyl) Anthranilic Acid (ACA) modulates the activity of different TRP channels independent of PLA2 2 inhibition.

Hazard Class

biological activity	N-(p-amylcinnamoyl) Anthranilic Acid (ACA) is an inhibitor of broad-spectrum phospholipase A2 (PLA2) and a blocker of TRP channel. N-(p-amylcinnamoyl) Anthranilic Acid (ACA) is also an effective reversible inhibitor of calcium-activated chloride channels (calcium-activated chloride channels), which has the potential to be used in arrhythmia related research.
target	PLA 2 . TRP channel. Calcium-activated chloride channels.

Last Update：2024-04-10 22:29:15

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