4-PyriMidinecarboxylic acid, 6-aMino-5-chloro-
6-Amino-5-chloro-4-pyrimidinecarboxylicacid
CAS: 914916-98-6
Molecular Formula: C5H4ClN3O2
4-PyriMidinecarboxylic acid, 6-aMino-5-chloro- - Names and Identifiers
4-PyriMidinecarboxylic acid, 6-aMino-5-chloro- - Physico-chemical Properties
| Molecular Formula | C5H4ClN3O2 |
| Molar Mass | 173.56 |
| Density | 1.690 |
| Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
4-PyriMidinecarboxylic acid, 6-aMino-5-chloro- - Introduction
It is an organic compound. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: White crystalline powder.
-Solubility: slightly soluble in water, soluble in acid and alkali solution.
-Melting point: approximately 292-296°C.
Use:
-is an important intermediate compound that can be used to synthesize pesticides, drugs, dyes and other organic compounds.
-It can be used as a raw material for the synthesis of pyrimidine compounds and participate in the construction of pyrimidine rings.
Method:
It can be synthesized by the following steps:
1. Aminopyrimidine reacts with chloroacetic acid under alkaline conditions to generate 6-chloro-5-aminopyrimidine.
2. then the 6-chloro -5-amino pyrimidine and carbamic acid reaction, removal of chlorine atoms, generation of 6-amino -5-chloropyrimidine.
3. Finally, 6-amino -5-chloropyrimidine is reacted with carbon dioxide under alkaline conditions to form a pyridine.
Safety Information:
-Toxicity information is limited, but should be considered toxic chemicals and handled in accordance with laboratory safety practices.
-When using chemicals or participating in the synthesis process, wear appropriate protective equipment, such as laboratory gloves and goggles, to avoid contact with skin and eyes.
-in the storage and handling of chemicals, should pay attention to the measures of fire and explosion prevention.
-If ingested or inhaled, seek medical help immediately and provide information about the chemical to your doctor.
Nature:
-Appearance: White crystalline powder.
-Solubility: slightly soluble in water, soluble in acid and alkali solution.
-Melting point: approximately 292-296°C.
Use:
-is an important intermediate compound that can be used to synthesize pesticides, drugs, dyes and other organic compounds.
-It can be used as a raw material for the synthesis of pyrimidine compounds and participate in the construction of pyrimidine rings.
Method:
It can be synthesized by the following steps:
1. Aminopyrimidine reacts with chloroacetic acid under alkaline conditions to generate 6-chloro-5-aminopyrimidine.
2. then the 6-chloro -5-amino pyrimidine and carbamic acid reaction, removal of chlorine atoms, generation of 6-amino -5-chloropyrimidine.
3. Finally, 6-amino -5-chloropyrimidine is reacted with carbon dioxide under alkaline conditions to form a pyridine.
Safety Information:
-Toxicity information is limited, but should be considered toxic chemicals and handled in accordance with laboratory safety practices.
-When using chemicals or participating in the synthesis process, wear appropriate protective equipment, such as laboratory gloves and goggles, to avoid contact with skin and eyes.
-in the storage and handling of chemicals, should pay attention to the measures of fire and explosion prevention.
-If ingested or inhaled, seek medical help immediately and provide information about the chemical to your doctor.
Last Update：2024-04-09 21:00:56
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View History
4-PyriMidinecarboxylic acid, 6-aMino-5-chloro-
1-Butanone, 1-(4-chlorophenyl)-2-hydroxy-3-methyl-
3-(5-METHYL-3-NITRO-PYRAZOL-1-YL)-PROPIONIC ACID METHYL ESTER
1-甲基-5-(对甲苯甲酰基)-2-吡咯乙酸甲酯
T-BUTYLDIMETHYLSILYLIMIDAZOLE
D**3-碘苯甲酸
哌拉西林甲酯杂质
1-[(tert-butoxy)carbonyl]-5-methylpiperidine-3-carboxylic acid
4-[4-ETHOXYCARBONYLPHENYLAMINOMETHYL]-BENZOIC ACID 2-(TRIMETHYLSILYL)-ETHYL ESTER
LL 1
1-Butanone, 1-(4-chlorophenyl)-2-hydroxy-3-methyl-
3-(5-METHYL-3-NITRO-PYRAZOL-1-YL)-PROPIONIC ACID METHYL ESTER
1-甲基-5-(对甲苯甲酰基)-2-吡咯乙酸甲酯
T-BUTYLDIMETHYLSILYLIMIDAZOLE
D**3-碘苯甲酸
哌拉西林甲酯杂质
1-[(tert-butoxy)carbonyl]-5-methylpiperidine-3-carboxylic acid
4-[4-ETHOXYCARBONYLPHENYLAMINOMETHYL]-BENZOIC ACID 2-(TRIMETHYLSILYL)-ETHYL ESTER
LL 1