4-Methyl-6-(trifluoromethyl)pyrimidine-2-amine - Names and Identifiers
4-Methyl-6-(trifluoromethyl)pyrimidine-2-amine - Physico-chemical Properties
Molecular Formula | C6H6F3N3
|
Molar Mass | 177.13 |
Density | 1.384g/cm3 |
Boling Point | 268.3°C at 760 mmHg |
Flash Point | 116°C |
Vapor Presure | 0.00776mmHg at 25°C |
Storage Condition | 2-8°C |
Refractive Index | 1.482 |
4-Methyl-6-(trifluoromethyl)pyrimidine-2-amine - Risk and Safety
Hazard Symbols | T - Toxic
|
Risk Codes | 25 - Toxic if swallowed
|
Safety Description | 45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
|
WGK Germany | 3 |
Hazard Class | IRRITANT |
4-Methyl-6-(trifluoromethyl)pyrimidine-2-amine - Introduction
4-methyl-6-(trifluoromethyl)pyrimidin-2-amine is an organic compound with the chemical formula C6H6F3N3. It is a white solid with low toxicity. Here is more detailed information about the compound:
Nature:
-Appearance: White solid
-Molecular weight: 177.12g/mol
-Melting point: 74-76°C
-Boiling Point: 209-210°C
-Solubility: Soluble in acid, alkali and some organic solvents
Use:
- 4-methyl-6-(trifluoromethyl)pyrimidin-2-amine is widely used in the field of medicine, as drug intermediates and synthetic raw materials.
-It is also used as an ingredient in pesticides and has bactericidal and herbicidal properties.
Preparation Method:
The preparation method of 4-methyl-6-(trifluoromethyl)pyrimidin-2-amine usually involves the following steps:
1.3-methyl pyrimidine as the starting material, its chlorination reaction to generate 3-chloromethyl pyrimidine.
2.3-chloromethylpyrimidine reacts with trifluoroformic acid to generate 2-chloro-4-trifluoromethyl-6-methylpyrimidine.
3. Finally, 2-chloro-4-trifluoromethyl-6-methylpyrimidine is reacted with amino base to generate 4-methyl-6-(trifluoromethyl)pyrimidin-2-amine.
Safety Information:
- 4-methyl-6-(trifluoromethyl)pyrimidin-2-amine is less dangerous, but it is still necessary to pay attention to safe operation.
-During operation, wear gloves, goggles and protective clothing to avoid contact with skin and eyes.
-When storing, keep it in a dry, dark place, and away from fire and oxidizing agents.
Please note that the specific properties, uses, preparation methods and safety information of this compound may vary slightly based on different references and literature. To ensure accuracy and safety, it is recommended that authoritative guidelines or professional guidance be consulted for the specific use, preparation, and disposal of this compound.
Last Update:2024-04-09 21:00:56