4-Hydroxy-3-nitro-2-pyridone
2,4-Dihydroxy-3-nitropyridine
CAS: 89282-12-2
Molecular Formula: C5H4N2O4
4-Hydroxy-3-nitro-2-pyridone - Names and Identifiers
4-Hydroxy-3-nitro-2-pyridone - Physico-chemical Properties
| Molecular Formula | C5H4N2O4 |
| Molar Mass | 156.1 |
| Density | 1.65±0.1 g/cm3(Predicted) |
| Melting Point | 265°C (dec.) |
| Boling Point | 305.6±42.0 °C(Predicted) |
| Appearance | Bright yellow crystal |
| BRN | 149558 |
| pKa | 4.50±1.00(Predicted) |
| Storage Condition | Inert atmosphere,Room Temperature |
| MDL | MFCD01075671 |
4-Hydroxy-3-nitro-2-pyridone - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S37 - Wear suitable gloves. |
| UN IDs | 3335 |
| HS Code | 29333990 |
4-Hydroxy-3-nitro-2-pyridone - Reference Information
| introduction | 2,4-dihydroxy -3-nitropyridine is white or light yellow solid at normal temperature and pressure. it belongs to pyridine heterocyclic compounds. due to the hydroxyl group in the structure, the enol structure is different to form a carbonyl structure to obtain the molecular structure of amide, it is a material additive and pharmaceutical chemical intermediate. |
| Use | 2, 4-dihydroxy-3-nitropyridine can be used as a material additive, pharmaceutical chemistry and organic synthesis intermediate. In the synthetic transformation, the hydroxyl group in the structure may be affected by the influence of cyclopyridine and nitro group and can be easily converted into halogen atoms, it should be noted that by changing the reaction conditions, two hydroxyl groups can selectively halogenate one or convert two at one time. In addition, liquid bromine can be used to introduce a bromine atom at the 5th position of pyridine under acidic conditions. |
| synthesis | 2, 4-dihydroxypyridine (13)(4.95kg, 43.2 mol) is slowly added into cooled (0-20 ℃) concentrated sulfuric acid (15 liters) in batches, and the reactants are stirred for 35 minutes, then slowly add fuming nitric acid (2L) at a rate of keeping the internal temperature below 5 degrees (adding time 4.5 hours), then add cold water (6 liters), and keep the internal temperature below 5 degrees (adding time 2.6 hours) and add the remaining 54 liters of water (adding time 1.25 hours) at a rate of raising the internal temperature to 15 degrees. The slurry is cooled to 8 degrees to obtain a precipitate, filtered (2 hours) and washed with water (2 × 20L), and the target product 2, 4-dihydroxy-3-nitropyridine is obtained by drying the solid in a 75-degree vacuum furnace under nitrogen atmosphere. Figure 2. Synthetic route of 4-dihydroxy-3-nitropyridine |
Last Update：2024-04-09 20:52:54
Supplier List
Product Name: 2,4-Dihydroxy-3-nitropyridine Request for quotation
CAS: 89282-12-2
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
CAS: 89282-12-2
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Spot supply
Product Name: 2,4-Dihydroxy-3-nitropyridine Request for quotationCAS: 89282-12-2
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3785839865
Wechat: chemical6666
Spot supply
Product Name: 24-Dihydroxy-3-nitropyridine Visit Supplier Webpage Request for quotationCAS: 89282-12-2
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Spot supply
Product Name: 2,4-Dihydroxy-3-nitropyridine Visit Supplier Webpage Request for quotationCAS: 89282-12-2
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: 2,4-Dihydroxy-3-nitropyridine Visit Supplier Webpage Request for quotationCAS: 89282-12-2
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Multiple Specifications
Product Name: 2,4-Dihydroxy-3-Nitropyridine Visit Supplier Webpage Request for quotationCAS: 89282-12-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Product Name: 2,4-Dihydroxy-3-nitropyridine Request for quotation
CAS: 89282-12-2
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228
Wechat: +8613651600618
WhatsApp: +8613651600618
CAS: 89282-12-2
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228
Wechat: +8613651600618
WhatsApp: +8613651600618
Product Name: 2,4-Dihydroxy-3-nitropyridine Request for quotation
CAS: 89282-12-2
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
CAS: 89282-12-2
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Spot supply
Product Name: 2,4-Dihydroxy-3-nitropyridine Request for quotationCAS: 89282-12-2
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3785839865
Wechat: chemical6666
Spot supply
Product Name: 24-Dihydroxy-3-nitropyridine Visit Supplier Webpage Request for quotationCAS: 89282-12-2
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Spot supply
Product Name: 2,4-Dihydroxy-3-nitropyridine Visit Supplier Webpage Request for quotationCAS: 89282-12-2
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: 2,4-Dihydroxy-3-nitropyridine Visit Supplier Webpage Request for quotationCAS: 89282-12-2
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Multiple Specifications
Product Name: 2,4-Dihydroxy-3-Nitropyridine Visit Supplier Webpage Request for quotationCAS: 89282-12-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Product Name: 2,4-Dihydroxy-3-nitropyridine Request for quotation
CAS: 89282-12-2
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228
Wechat: +8613651600618
WhatsApp: +8613651600618
CAS: 89282-12-2
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228
Wechat: +8613651600618
WhatsApp: +8613651600618
View History
4-Hydroxy-3-nitro-2-pyridone
Cyclopentanecarboxylic acid, 1-[[(phenylmethoxy)carbonyl]amino]-, methyl ester
3-Hydroxy ClonazepaM
1-(3-氟苯基)-3-(3-((7-(1-甲基-1H-吡唑-4-基)喹唑啉-4-基)氨基)苯基)脲
[(3R)-3-PIPERIDINYLMETHYL]-CARBAMIC ACID PHENYLMETHYL ESTER HYDROCHLORIDE
(R)-4-叔丁基-2-[2-(二苯基膦基)苯基]-2-噁唑啉
2-氨基-5,6-二氢-4H-环戊烯并噻吩-3-甲酸甲酯
4-三甲基甲硅烷基-3-丁炔-1-醇
Hex-5-en-2-Ylboronic Acid
2-(3-(Trifluoromethoxy)phenyl)propan-2-amine
Cyclopentanecarboxylic acid, 1-[[(phenylmethoxy)carbonyl]amino]-, methyl ester
3-Hydroxy ClonazepaM
1-(3-氟苯基)-3-(3-((7-(1-甲基-1H-吡唑-4-基)喹唑啉-4-基)氨基)苯基)脲
[(3R)-3-PIPERIDINYLMETHYL]-CARBAMIC ACID PHENYLMETHYL ESTER HYDROCHLORIDE
(R)-4-叔丁基-2-[2-(二苯基膦基)苯基]-2-噁唑啉
2-氨基-5,6-二氢-4H-环戊烯并噻吩-3-甲酸甲酯
4-三甲基甲硅烷基-3-丁炔-1-醇
Hex-5-en-2-Ylboronic Acid
2-(3-(Trifluoromethoxy)phenyl)propan-2-amine