4-Borono-2-bromo-5-chloropyridine - Risk and Safety
Hazard Symbols
Xi - Irritant
Hazard Note
Irritant
4-Borono-2-bromo-5-chloropyridine - Introduction
boronic acid is an organic compound with the chemical formula C5H4BBrClNO2.
Nature:
(br) boronic acid is a white crystalline powder. It is a low solubility and can be dissolved in polar solvents such as ethanol and dimethyl sulfoxide, but has low solubility in non-polar solvents. It is a weak acid that can react with alkali to form the corresponding salts.
Use:
boronic acid is an important intermediate commonly used in organic synthesis. It can participate in metal-catalyzed cross-coupling reactions such as Suzuki reaction and Negishi reaction, and can be used as a synthetic intermediate of aromatic compounds. In addition, it can also be used for the preparation of pesticides, pharmaceuticals and pesticide derivatives.
Preparation Method:
() There are many preparation methods for boronic acid, and the commonly used method is synthesis by coupling reaction. A common preparation method is to react 2-bromo-5-chloropyridin-4-ol and triphenylboron chloride in the presence of a base and a solvent, followed by hydrolysis to obtain the target product.
Safety Information:
(br) boronic acid may be irritating and dangerous to the human body, it is necessary to pay attention to safety measures during operation, such as wearing protective gloves and glasses. At the same time, in the process of storage and handling to seal preservation, avoid contact with oxidants, acids and alkalis and other substances.