4-(5-氯-1H-吲唑-3-基)哌啶-1-甲酸叔丁酯

4-(5-氯-1H-吲唑-3-基)哌啶-1-甲酸叔丁酯 - Names and Identifiers

Name	tert-Butyl 4-(5-chloro-1H-indazol-3-yl)piperidine-1-carboxylate
Synonyms	tert-Butyl 4-(5-chloro-1H-indazol-3-yl)piperidin-1-carboxylate tert-Butyl 4-(5-chloro-1H-indazol-3-yl)piperidine-1-carboxylate tert-butyl 4-(5-chloro-2H-indazol-3-yl)piperidine-1-carboxylate 1-Piperidinecarboxylic acid, 4-(5-chloro-1H-indazol-3-yl)-, 1,1-dimethylethyl ester
CAS	1198284-74-0

4-(5-氯-1H-吲唑-3-基)哌啶-1-甲酸叔丁酯 - Physico-chemical Properties

Molecular Formula	C17H22ClN3O2
Molar Mass	335.83
Density	1.260±0.06 g/cm3(Predicted)
Boling Point	493.4±45.0 °C(Predicted)
pKa	12.89±0.40(Predicted)
Storage Condition	Room Temprature
Sensitive	Irritant
MDL	MFCD12912623

4-(5-氯-1H-吲唑-3-基)哌啶-1-甲酸叔丁酯 - Introduction

tert-Butyl 4-(5-chroo-1H-indazol-3-yl) piperidine-1-carboxylate is an organic compound. Its chemical formula is C19H26ClN3O2 and its molecular weight is 361.88g/mol. The following is a description of the properties, uses, preparation and safety information of the compound:

Nature:
-Appearance: White crystalline solid
-Melting point: 70-72°C
-Solubility: Soluble in organic solvents such as methanol, dichloromethane and chloroform

Use:
-Chemical reagent: can be used as a reagent in organic synthesis
-Drug research: The compound has potential biological activity in the field of drug research and can be used to study the synthesis and properties of new drugs

Preparation Method:
The preparation of this compound usually involves the following steps:
1.4-piperidinecarboxylic acid tert-butyl ester and stannous chloride methyl ruthenium treatment.
2. A condensation reagent of substituted piperidine is added and heated to react.
3. adding aluminum chloride and other reagents, chlorination reaction, generate the target product.
4. After the crystallization purification step, a white crystalline solid product was obtained.

Safety Information:
-This compound may be harmful to the human body and may cause irritation to the respiratory system, skin and eyes. When handling, wear protective gloves, safety glasses and protective face mask.
-Avoid inhaling the dust or gas of the compound and use it in a well-ventilated place.
-Try to avoid direct contact with skin and eyes. If discomfort occurs after contact, rinse with plenty of water immediately and seek medical help.
-The compound should be kept away from ignition and oxidizing agents, stored properly, and avoid mixing with other chemicals.

Last Update：2024-04-09 15:18:08