Molecular Formula | C21H19N3O2S |
Molar Mass | 377.46 |
Solubility | Soluble in DMSO (up to 20 mg/ml). |
Appearance | solid |
Color | Yellow |
Storage Condition | RT |
Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months. |
MDL | MFCD00358662 |
In vitro study | The fluorescence intensities of phagocytosed beads or bacteria in hemocytes, taken as a measure of phagocytosis efficiency, were markedly reduced in granulocytes treated with MLS-573151 (50 μM; for 15 min) compared to that in the control group. MLS-573151 could effectively inhibit the phagocytic ability of granulocytes. |
biological activity | MLS-573151 (MLS000573151) is a selective inhibitor of GTPase Cdc42 with an EC50 of 2 μm. MLS-573151 is not effective against other GTPases family members such as Rab2,Rab7,H-Ras,Rac1,Rac 2 and RhoA wild-type. MLS-573151 works by preventing GTP from binding to Cdc42. |