4,6-二氯-2-乙氧基嘧啶
4,6-Dichloro-2-ethoxypyrimidine
CAS: 40758-65-4
Molecular Formula: C6H6Cl2N2O
4,6-二氯-2-乙氧基嘧啶 - Names and Identifiers
| Name | 4,6-Dichloro-2-ethoxypyrimidine |
| Synonyms | 2-ETHOXY-4,6-DICHLOROPYRIMIDINE 4,6-Dichloro-2-ethoxypyrimidine 4,6-DICHLORO-2-ETHOXYPYRIMIDINE Pyrimidine, 4,6-dichloro-2-ethoxy- |
| CAS | 40758-65-4 |
| InChI | InChI=1/C6H6Cl2N2O/c1-2-11-6-9-4(7)3-5(8)10-6/h3H,2H2,1H3 |
4,6-二氯-2-乙氧基嘧啶 - Physico-chemical Properties
| Molecular Formula | C6H6Cl2N2O |
| Molar Mass | 193.03 |
| Density | 1.375±0.06 g/cm3(Predicted) |
| Boling Point | 283.5±43.0 °C(Predicted) |
| Flash Point | 125.236°C |
| Vapor Presure | 0.005mmHg at 25°C |
| pKa | -4.46±0.30(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Refractive Index | 1.533 |
| Physical and Chemical Properties | 4,6-Dichloro-2-ethoxypyrimidine |
4,6-二氯-2-乙氧基嘧啶 - Reference Information
| Application | 2-ethoxy -4, 6-dichloropyrimidine is an important heterocyclic pesticide and pharmaceutical intermediate. It can be used to synthesize high-efficiency herbicides containing triazole pyrimidine rings, such as diclofenamine and chloroxenamine; it can also be used to synthesize certain antibiotic drugs. Therefore, 2-ethoxy-4, 6-dichloropyrimidine has broad application prospects in organic synthesis, medicine, pesticides and other fields. |
| preparation | 39.0g of 2-methylthio -4,6-dichloropyrimidine (0.2mol), 60.0g of methanol and 1.8g of sodium tungstate are added to a 250mL reaction bottle equipped with a thermometer and a stirrer, stirring and heating to 50 ℃, dropping 68.0g of hydrogen peroxide (0.6mol) with a concentration of 30wt%, and exothermic reaction. After dropping the heat preservation reaction for 1h, sampling and analysis will stop the reaction when the raw material is less than or equal to 0.5%. The reaction system was reduced to below 30 ℃, then added to water, stirred and cooled to below 5 ℃, filtered, and the filter cake was washed with a small amount of water and dried directly to obtain 43.5g of 2-methylsulfonyl -4, 6-dichloropyrimidine with a yield of 95.8% and a purity of 98.5%(HPLC). Add 43.5g of 2-methylsulfonyl -4, 6-dichloropyrimidine (0.19mol) and 90g of ethanol to a 500mL reaction bottle equipped with a thermometer and a stirrer, stir at room temperature, then cool to 0 ℃, and drop 130g of sodium ethoxide solution (0.38mol) with a concentration of 20wt%. After dropping the heat preservation reaction for 1h, sampling and analysis will stop the reaction when the raw material is less than 1%. After adjusting the pH of the reaction system with a small amount of glacial acetic acid to be about neutral, ethanol is recovered at normal pressure, water and dichloromethane are added after steaming, stirred and stratified, the organic layer is washed once, the solvent is recovered at normal pressure and then reduced pressure until no liquid flows out, and the target product 2-ethoxy -4, 6-dichloropyrimidine of 35.2g of the product is obtained with a yield of 95.2% and a purity of 96.5%(HPLC). |
Last Update：2024-04-09 15:16:50
Supplier List
Spot supply
Product Name: 2-ETHOXY-4,6-DICHLOROPYRIMIDINE Visit Supplier Webpage Request for quotationCAS: 40758-65-4
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: 2-Ethoxy-4,6-dichloropyrimidine Visit Supplier Webpage Request for quotationCAS: 40758-65-4
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Product Name: 2-ETHOXY-4,6-DICHLOROPYRIMIDINE Visit Supplier Webpage Request for quotation
CAS: 40758-65-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 40758-65-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Spot supply
Product Name: 2-ETHOXY-4,6-DICHLOROPYRIMIDINE Visit Supplier Webpage Request for quotationCAS: 40758-65-4
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: 2-Ethoxy-4,6-dichloropyrimidine Visit Supplier Webpage Request for quotationCAS: 40758-65-4
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Product Name: 2-ETHOXY-4,6-DICHLOROPYRIMIDINE Visit Supplier Webpage Request for quotation
CAS: 40758-65-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 40758-65-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History
4,6-二氯-2-乙氧基嘧啶
undec-2-enol
8-氨基-2-甲基咪唑并[1,2-A]吡嗪
453-14-5 1,3-二氟丙酮
(6-ETHYL-2-METHYL-THIENO[2,3-D]PYRIMIDIN-4-YLSULFANYL)-ACETIC ACID
绵羊胰岛素(INSULIN)ELISA试剂盒
5,11-二氢-11-[(4-甲基哌嗪-1-基)乙酰基]-6H-吡啶并[2,3-B][1,4]苯并二氮杂卓-6-酮
5-羟基-2-甲基苯并噻唑
ART-CHEM-BB B015583
N-(1-Hydroxy-2-butyl)furan-2-carboxaMide
undec-2-enol
8-氨基-2-甲基咪唑并[1,2-A]吡嗪
453-14-5 1,3-二氟丙酮
(6-ETHYL-2-METHYL-THIENO[2,3-D]PYRIMIDIN-4-YLSULFANYL)-ACETIC ACID
绵羊胰岛素(INSULIN)ELISA试剂盒
5,11-二氢-11-[(4-甲基哌嗪-1-基)乙酰基]-6H-吡啶并[2,3-B][1,4]苯并二氮杂卓-6-酮
5-羟基-2-甲基苯并噻唑
ART-CHEM-BB B015583
N-(1-Hydroxy-2-butyl)furan-2-carboxaMide