Molecular Formula | C6H5F4N3O2 |
Molar Mass | 227.12 |
Density | 1.527 |
Boling Point | 337°C |
Flash Point | 157°C |
Vapor Presure | 0.0248mmHg at 25°C |
Storage Condition | 2-8°C |
Refractive Index | 1.428 |
Physical and Chemical Properties | Density 1.527 boiling point 337°C flash point 157°C |
Use | 2-amino -4, 6-bis-(difluoromethoxy) pyrimidine is an intermediate of the sulfonylurea herbicide flumsulfuron-methyl. |
production method | the preparation method is to add 4, 6-dihydroxy-2-methylthiopyrimidine disodium salt and phase transfer catalyst, acetonitrile solvent, heated to 50 ℃, in 10 min through difluoro-chloromethane, reactor pressure is 200kPa, after 6h of reaction, the pressure was relieved by cooling, the product was filtered, the residue was washed with acetonitrile, the filtrate and washings were combined, and the solvent was removed by heating to give 4, 6-bis-(difluoromethoxy)-2-methylthiopyrimidine. Add the above 4, 6-bis-(difluoromethoxy)-2-methylthiopyrimidine and glacial acetic acid into the reaction bottle, raise the temperature to 80~85 ℃, then add 30% hydrogen peroxide Dropwise, stirring was continued at this temperature for 2H, and the reaction product was poured into water, extracted with dichloromethane, then de-solvated by heating and recrystallized to give 4,6-bis-(difluoromethoxy)-2-methanesulfonylpyrimidine. The above methanesulfonylpyrimidine and dichloromethane were added into three vials, and stirred at room temperature, and 30% aqueous ammonia solution was added dropwise. After the addition was completed, stirring was continued for 30min, and the reaction was heated and refluxed for 2H, and then the solvent was removed to obtain a finished product. |