4,5-DIFLUORO-2-NITROANILINE - Names and Identifiers
Name | 4,5-difluoro-2-nitroaniline
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Synonyms | 4,5-DIFLUORO-2-NITRO 3,4-DIFLUORO-2-NITROANILINE 4,5-difluoro-2-nitroaniline 4,5-DIFLUORO-2-NITROANILINE 4,5-Difluoro-2-Nitro-Aniline 3,4-DIFLUORO-6-NITRO ANILINE 2-Amino-4,5-difluoronitrobenzene Benzenamine, 4,5-difluoro-2-nitro-
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CAS | 78056-39-0
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InChI | InChI=1/C6H4F2N2O2/c7-3-1-5(9)6(10(11)12)2-4(3)8/h1-2H,9H2 |
InChIKey | WDMCABATCGQAKK-UHFFFAOYSA-N |
4,5-DIFLUORO-2-NITROANILINE - Physico-chemical Properties
Molecular Formula | C6H4F2N2O2
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Molar Mass | 174.1 |
Density | 1.554±0.06 g/cm3(Predicted) |
Melting Point | 107-108 °C (lit.) |
Boling Point | 308.1±37.0 °C(Predicted) |
Flash Point | 140.143°C |
Solubility | soluble in Methanol |
Vapor Presure | 0.001mmHg at 25°C |
Appearance | Yellow powder |
Color | Golden to orange |
BRN | 2723242 |
pKa | -1.25±0.25(Predicted) |
Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
Refractive Index | 1.575 |
MDL | MFCD00010876 |
Use | Usually used in in the preparation of 2-chloro-5,6-difluorobenzimidazole and 5-ethoxy-6-fluorobenzofuroxan, also used in the preparation of 1-(4,5-difluoro-2-nitrophenyl)pyrene via diazotization reaction with isoamyl nitrite in the presence of pyrene |
4,5-DIFLUORO-2-NITROANILINE - Risk and Safety
Hazard Symbols | Xi - Irritant
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Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin.
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Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
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UN IDs | 2811 |
WGK Germany | 3 |
FLUKA BRAND F CODES | 10 |
HS Code | 29214200 |
Hazard Note | Irritant |
Hazard Class | 6.1(b) |
Packing Group | III |
4,5-DIFLUORO-2-NITROANILINE - Introduction
4,5-difluoro-2-nitroaniline is an organic compound with the chemical formula C6H4F2N2O2. The following is a description of its nature, use, formulation and safety information:
Nature:
-Appearance: 4,5-difluoro-2-nitroaniline is a yellow crystalline powder.
-Solubility: It is soluble in common organic solvents such as ethanol, dimethyl sulfoxide and dichloromethane.
-Boiling point: This compound has a relatively high boiling point, about 315-317°C.
Use:
-Chemical research: 4,5-difluoro-2-nitroaniline can be used in organic synthesis and pharmaceutical research.
-Dye synthesis: It can be used as a raw material for dyes and pigments.
-Pesticide synthesis: The derivatives of this compound can be used to synthesize pesticides.
Preparation Method:
The preparation method of 4,5-difluoro-2-nitroaniline usually involves the nitration and fluorination of aniline compounds.
1. First, aniline reacts with concentrated nitric acid and is treated with sodium nitrite or ammonium nitrite to generate 2-nitroaniline.
2. Then, 2-nitroaniline is reacted with chloromethane fluoride or bromine trifluoride to generate 4,5-difluororo-2-nitroaniline.
Safety Information:
- 4,5-difluoro-2-nitroaniline may be harmful to human health when overexposed or exposed. It can irritate the eyes, skin, and respiratory tract, and may cause damage to the nervous system, liver, and kidneys.
-Use in accordance with safe practices, such as wearing appropriate personal protective equipment (e. g. gloves, goggles and protective masks) and operating in well-ventilated areas.
-If you come into contact with this compound, immediately flush the affected area with plenty of water and seek medical help.
Please note that the use of any chemicals should follow the correct experimental procedures and safety instructions, and be handled and stored in strict accordance with relevant regulations and laws.
Last Update:2024-04-09 21:01:54