3beta,17-dihydroxy-16alpha-methylpregn-5-en-20-one

3beta,17-dihydroxy-16alpha-methylpregn-5-en-20-one - Names and Identifiers

Name	3beta,17-dihydroxy-16alpha-methylpregn-5-en-20-one
Synonyms	16-Methylpregn-5-ene-3,17-diol-20-one 3,17-Dihydroxy-16-methylpregn-5-en-20-one 3beta,17-dihydroxy-16alpha-methylpregn-5-en-20-one 1-((3S,8R,9S,10R,13S,14S,16R,17R)-3,17-dihydroxy-10,13,16-trimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)ethanone
CAS	4927-26-8
EINECS	2255579

3beta,17-dihydroxy-16alpha-methylpregn-5-en-20-one - Physico-chemical Properties

Molecular Formula	C22H34O3
Molar Mass	346.50356
Density	1.13±0.1 g/cm3(Predicted)
Melting Point	253-255 °C
Boling Point	483.9±45.0 °C(Predicted)
pKa	13.04±0.70(Predicted)
Physical and Chemical Properties	Crystallization of chemical properties. Melting point 210 ℃.
Use	Use intermediate of dexamethasone acetate.

3beta,17-dihydroxy-16alpha-methylpregn-5-en-20-one - Production method

You can use 3 β-hydroxyprogesterone -5,16-diene -20-keto -3-acetate, (I. e. gestational dienolone acetate), through the (16-position double bond and methonitromethylurea) Addition and elimination to generate 3 β-hydroxy-16 β-methylprogesterone -5,16-diene -20-keto -3-acetate, then it is catalyzed by (16-position double bond) epoxidation, (epoxy group) ring opening (forming 17 α-hydroxyl and 15-position double bond), (15-position double bond) hydrogenation and hydrolysis (removal of 3-position acetyl group) to prepare the product.

Last Update：2024-04-10 22:29:15