Molecular Formula | C22H35NO4 |
Molar Mass | 377.52 |
Density | 1.30±0.1 g/cm3 (20 ºC 760 Torr) |
Melting Point | 185-186℃ (acetone ) |
Boling Point | 540.2±50.0 °C(Predicted) |
pKa | 13.80±0.70(Predicted) |
Storage Condition | 2-8°C |
RTECS | AR5569480 |
Overview | Aconitum Thunb (aconifolium cuspidata) is the dried root of the North aconite of The Ranunculaceae family, which has a long history of folk medicine, commonly used in the treatment of rheumatism, paralysis, cold hernia, pain and other symptoms. Diterpenoid alkaloids are the main bioactive components of aconitine, and multiroot aconitine is one of its active substances. They are not only the main medicinal ingredients, but also highly toxic ingredients, improper use of drugs is easy to cause poisoning phenomenon. Therefore, in order to ensure the safety of drug use, it is necessary to clarify the types of all alkaloids in aconitum and strictly control the content of these alkaloids in the medicinal materials by content determination. |
Use | multiroot aconitine is the active extract of Aconitum, which is commonly used in the treatment of rheumatism, paralysis, cold hernia, pain and other symptoms. |
biological activity | Karacoline is a diterpenoid alkaloid found in the plant Aconitum kusnezoffii, it can reduce the degradation of extracellular matrix in intervertebral disc degeneration through NF-κB signaling pathway. |