37535-58-3 - Names and Identifiers
Name | (R)-N-Boc-(4-Pyridyl)alanine
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Synonyms | Boc-D-4-Pal-OH RARECHEM BK PT 0243 Boc-D-4-Pyridylalanine Boc-D-3-(4-Pyridyl)-alanine Boc-3-(4-Pyridyl)-D-alanine (R)-N-BOC-(4-PYRIDYL)ALANINE (R)-N-Boc-(4-Pyridyl)alanine (R)-2-TERT-BUTOXYCARBONYLAMINO-3-PYRIDIN-4-YL-PROPIONIC ACID (2R)-2-{[(tert-butoxy)carbonyl]aMino}-3-(pyridin-4-yl)propanoic acid (R)-N-BOC-(4-Pyridyl)alanineN-tert-Butoxycarbonyl-4-pyridyl-D-alanine N-(tert-Butoxycarbonyl)-3-(pyridin-4-yl)-D-alanine, (2R)-2-[(tert-Butoxycarbonyl)amino]-3-(pyridin-4-yl)propanoic acid
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CAS | 37535-58-3
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InChI | InChI=1/C13H18N2O4/c1-13(2,3)19-12(18)15-10(11(16)17)8-9-4-6-14-7-5-9/h4-7,10H,8H2,1-3H3,(H,15,18)(H,16,17)/p-1/t10-/m1/s1 |
37535-58-3 - Physico-chemical Properties
Molecular Formula | C13H18N2O4
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Molar Mass | 266.3 |
Density | 1.1738 (rough estimate) |
Melting Point | 223-229°C |
Boling Point | 409.5°C (rough estimate) |
Flash Point | 228.5°C |
Vapor Presure | 4.82E-09mmHg at 25°C |
Appearance | Powder |
Color | White |
BRN | 4195478 |
pKa | 3.43±0.10(Predicted) |
Storage Condition | Inert atmosphere,2-8°C |
Sensitive | Air & Moisture Sensitive |
Refractive Index | 1.6450 (estimate) |
37535-58-3 - Risk and Safety
Hazard Symbols | Xi - Irritant
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Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin.
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Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36 - Wear suitable protective clothing.
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WGK Germany | 3 |
HS Code | 29223900 |
Hazard Class | IRRITANT |
37535-58-3 - Introduction
The (R)-N-Boc-(4-Pyridyl)alanine, also known as (R)-N-Boc-(4-Pyridyl)alanine, is a commonly used amino acid protecting group. The properties of the compound are as follows:
1. Appearance: Usually a white crystalline solid.
2. molecular formula: C15H20N2O4, relative molecular mass of 296.33.
3. Solubility: Soluble in some organic solvents such as dimethylformamide (DMF) and dimethyl sulfoxide (DMSO).
(R)-N-Boc-(4-Pyridyl)alanine is mainly used as an amino acid protecting group in the field of organic synthesis, which is used to protect one end functional group of amino acid in the process of synthesizing polypeptide or drug, so as to prevent it from being affected by unexpected chemical reaction, so as to ensure selective reaction at a specific site.
The preparation of (R)-N-Boc-(4-Pyridyl)alanine can be carried out by the following steps:
1. 4-pyridinecarboxaldehyde reacts with bromopropionate to give 3-(4-pyridyl)-propionate.
2. Reaction of 3-(4-pyridyl)-propionate with an amino acid protecting agent Boc-OSu to generate the target product (R)-N-Boc-(4-Pyridyl)alanine.
When using the (R)-N-Boc-(4-Pyridyl)alanine, you need to pay attention to the following safety information:
1. the compound may be irritating to the eyes, skin and respiratory tract, need to wear protective glasses, gloves and protective masks.
2. Avoid inhaling the dust of the compound or the vapor of the solution, and operate in a well-ventilated place.
3. during use, attention should be paid to prevent the contact and intake of the compound, and avoid accidental ingestion or accidental skin absorption.
4. need to be stored in a dry, cool, ventilated place, away from the fire and flammable materials.
When using (R)-N-Boc-(4-Pyridyl)alanine in the laboratory, it should be operated in accordance with relevant chemical safety operation specifications and methods.
Last Update:2024-04-09 19:05:49