370-86-5
carbonyl cyanide 4-trifluoromethoxy phenylhydrazone
CAS: 370-86-5
Molecular Formula: C10H5F3N4O
370-86-5 - Names and Identifiers
370-86-5 - Physico-chemical Properties
| Molecular Formula | C10H5F3N4O |
| Molar Mass | 254.17 |
| Density | 1.34±0.1 g/cm3(Predicted) |
| Melting Point | 174-175°C (dec.)(lit.) |
| Boling Point | 293.3±50.0 °C(Predicted) |
| Flash Point | 131.2°C |
| Solubility | acetone: 20mg/mL, clear, very deep greenish yellow |
| Vapor Presure | 0.00174mmHg at 25°C |
| Appearance | powder |
| Color | yellow |
| BRN | 664446 |
| pKa | 5.91±0.10(Predicted) |
| Storage Condition | 2-8°C |
| Stability | Stable for 2 years from date of purchase as supplied. Protect from exposure to moisture. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months. |
| Refractive Index | 1.522 |
| In vitro study | In Vitro, FCCP treatment induced a rapid increase of intracellular Ca2 to 2-fold, while inhibiting the rate of protein synthesis. The inhibition of protein translation rate is associated with increased phosphorylation of eIF2α and increased activity of double-stranded RNA-dependent protein kinases. FCCP also slightly reduced ATP and reactive oxygen species levels, increased the expression of mitochondrial genes such as Tfam and COXIV, induced static morphological characteristics of mouse hematopoietic stem cells, and inhibited TGF-β signaling. |
| In vivo study | FCCP treatment significantly reduced mitochondrial membrane potential, ATP production and the number of intracellular cell mass in the blastocyst in the 8-cell stage mouse embryo, and had no effect on blastocyst development. While Embryonic mitochondrial function is disturbed, the birth weight of the female offspring decreases after embryo implantation, and the inhibition persists until the weaning stage. Although FCCP-treated male mice also had reduced glucose tolerance as did female mice. However, their insulin sensitivity and obesity did not change in 4-14 weeks. In prepress embryos, reduced mitochondrial function, followed by reduced ATP output, will affect their progeny phenotype. |
370-86-5 - Risk and Safety
| Risk Codes | R25 - Toxic if swallowed R43 - May cause sensitization by skin contact |
| Safety Description | S36/37 - Wear suitable protective clothing and gloves. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 2811 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | FG5775000 |
| Hazard Note | Irritant |
| Hazard Class | 6.1(a) |
| Packing Group | II |
370-86-5 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.934 ml | 19.672 ml | 39.344 ml |
| 5 mM | 0.787 ml | 3.934 ml | 7.869 ml |
| 10 mM | 0.393 ml | 1.967 ml | 3.934 ml |
| 5 mM | 0.079 ml | 0.393 ml | 0.787 ml |
Last Update：2024-01-02 23:10:35
370-86-5 - Reference Information
| biological activity | FCCP (Trifluoromethoxy carbonylcyanide phenylhydrazone, Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone) is an effective oxidative phosphorylation uncoupling agent in mitochondria, which destroys ATP synthesis by transporting protons. |
| Target | Value |
| Use | A proton carrier (H ionophore), which is also an uncoupling agent for mitochondrial oxidative phosphorylation. It can promote depolarization of plasma membrane and mitochondrial membrane. FCCP can affect various activities involved in cell calcium ions. It can also inhibit K background current and induce a small amount of inward current, reduce the pH of 0.1 units, and induce intracellular [Na] increase. FCCP can stimulate Mg2-ATPase activity, inhibit β-amyloid production, and simulate the effect of selective glutamate receptor agonist N-methyl-D-aspartate (NMDA) on mitochondrial superoxide production. |
Last Update：2024-04-10 22:29:15
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View History
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