Molecular Formula | C57H79N17O15 |
Molar Mass | 1242.36 |
Melting Point | >155oC (dec.) |
Solubility | Methanol (Slightly), Water (Slightly) |
Appearance | Solid |
Color | White to Off-White |
Storage Condition | Hygroscopic, Refrigerator, Under inert atmosphere |
Stability | Hygroscopic |
Use | Prostate cancer treatment |
medicinal properties and application | the secretion of goserelin acetate in the body by the sagging brain, can stimulate the anterior pituitary gland secretion of gonadotropin FSH, LH. LH can promote the synthesis and secretion of androgen in male testis. LH, FSH dual role can promote ovarian synthesis and secretion of estrogen. Continuous application of this product has a biphasic effect on the pituitary gland: it can promote the secretion of LH and FSH in the anterior pituitary gland, and increase the LH, FSH and sex hormones in the plasma; Over time, it can lead to the reduction of LHRH receptors in the pituitary gland, blocking the secretion of LH in the pituitary gland, thereby blocking the synthesis and secretion of testosterone, to achieve the same effect as orchiectomy. In women, the synthesis and secretion of estrogen is blocked to achieve the effect of ovariectomy. Therefore, it can treat hormone-dependent prostate cancer and breast cancer, and is also suitable for endometriosis. This product is mainly used as ovulation-promoting drug in clinic to treat infertility and primary ovarian insufficiency caused by hypothalamic amenorrhea, especially for those ineffective by clomiphene. It is also used for children with cryptorchidism and hyperandrogenism, pituitary tumor. Intravenous injection of 3min peak. t1/2 is about 6min, which is rapidly metabolized by the kidney. |
medication method | There are two methods: intravenous drip and nasal drip. Intravenous drip: 2~4 days of menstrual cycle, 5~20 μg, 90min in total. If there is no ovulation (the basal body temperature was measured), the drug could be given again. After ovulation, HCG1500 units were injected intramuscularly, and 1500 units were injected 3 days later. General 2~4 cycles can be pregnant. Nasal administration: for children with cryptorchidism, 1~2 years old for the best treatment time, 0.2mg, Early, Middle and Late 3 Spray, 4 weeks for a course of treatment, the interval can be repeated after 3 months. |
caution and contraindication | multiple pregnancies, inflammation at injection site and occasionally transient penile hypertrophy may occur during use of goserelin acetate. Allergic to benzyl alcohol should not be used. The injections were stored at 2-8 ℃ for shading, and the injections were stored at 8-20 ℃. |