3-(p-Chlorophenethyl)picolinonitrile is an organic compound with the chemical formula C14H11ClN2. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: White crystalline solid.
-Melting point: about 68-72°C.
-Solubility: Soluble in some organic solvents, such as methanol, chloroform and ethanol, insoluble in water.
Use:
- 3-(p-Chlorophenethyl)picolinonitrile can be used as a pharmaceutical intermediate in the treatment of depression and anxiety.
-It can also be used to synthesize other organic compounds, such as medicines, pesticides and dyes.
Preparation Method:
- 3-(p-Chlorophenethyl)picolinonitrile is generally synthesized by adding chlorophenylacetic acid and sulfuric acid to 2-picolinonitrile, and reacting with tetrabutylammonium hydroxide (TBAB) as a catalyst.
Safety Information:
- 3-(p-Chlorophenethyl)picolinonitrile should be careful to prevent contact with skin, eyes and respiratory tract during use and storage, and avoid inhalation or ingestion.
-It is irritating and may cause damage to the respiratory system, eyes and skin.
-In the operation, should wear protective gloves, protective glasses and masks, pay attention to good ventilation conditions.
-In case of accidental contact, rinse the area immediately with plenty of water and seek medical help.